| 两种生物材料修补大鼠腹壁缺损的组织学反应 |
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| 引用本文： | 李基业,邓群,黎沾良. 两种生物材料修补大鼠腹壁缺损的组织学反应[J]. 中国组织工程研究与临床康复, 2003, 7(29): 3932-3933 |
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| 作者姓名： | 李基业 邓群 黎沾良 |
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| 作者单位： | 解放军第三○四医院普外科,北京市,100037 |
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| 摘 要： | 目的:观察聚丙烯(Polypropylene,PP)和复合材料(Polypropylene+ex-pandedPolytetrafluoroethylene,PP+ePTFE)修补大鼠腹壁缺损的组织学反应,客观地评价两种材料的特点,以便为临床选用材料提供一定的理论依据。方法:Wistar大鼠分为PP全层修补(PP-T)组、PP保留腹膜(PP-PR)组和PP+ePTFE全层修补(PP+ePTFE-T)组。切除1.5cm(2.0cm的前腹壁,分别以相同面积的两种补片修补缺损,于术后14,30,60和120d进行腹腔内粘连评分及组织学检查。结果:PP+ePTFE组动物术后各期腹腔粘连明显轻于PP+T组(分别P<0.05)。PP+PR组动物腹腔无粘连。术后14d,两种材料周围均以炎性反应为主,但PP+ePTFE组腹腔面反应很轻。30d后,在PP和PP+ePTFE非腹腔面周围成纤维细胞和胶原逐渐增加。PP+ePTFE材料的腹腔面逐渐形成一间皮层。结论:PP材料与组织掺和好,但与腹腔粘连重。PP+ePTFE材料既有组织掺和好,又具有抗腹腔粘连作用。腹膜是防止PP材料与腹腔脏器粘连的最好屏障。
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| 关 键 词： | 聚丙烯类 聚四氟乙烯 腹部损伤 |
| 文章编号： | 1671-5926(2003)29-3932-02 |
| 修稿时间： | 2003-06-29 |
Experimental study on histological reaction of the two biomaterials in repairing abdominal wall defect |
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| Ji Ye Li,Qun Deng,Zhan Liang LiJi Ye Li,Qun Deng,Zhan Liang Li. Experimental study on histological reaction of the two biomaterials in repairing abdominal wall defect[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2003, 7(29): 3932-3933 |
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| Authors: | Ji Ye Li Qun Deng Zhan Liang LiJi Ye Li Qun Deng Zhan Liang Li |
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| Affiliation: | Ji Ye Li,Qun Deng,Zhan Liang LiJi Ye Li,Qun Deng,Zhan Liang Li,Department of General Surgery,The 304 Hospital of PLA,Beijing 100037,China |
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| Abstract: | |
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| Keywords: | S:The present study shows that the incorporation of PP with tissue is optimal though it has a high adhesion with the viscera. PP? ePTFE has the advantages of both good incorporation with tissue and less viscera adhesion. The peritoneum is the |
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