Parameters related to a positive test result for FDG PET(/CT) for large vessel vasculitis: a multicenter retrospective study |
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Authors: | G A Hooisma H Balink P M Houtman R H J A Slart K D F Lensen |
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Institution: | (1) Department of Nuclear Medicine, Medical Center Leeuwarden, Leeuwarden, The Netherlands;(2) Department of Internal Medicine, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands;(3) Department of Rheumatology, Medical Center Leeuwarden, Leeuwarden, The Netherlands;(4) Department of Nuclear Medicine, University Medical Center Groningen, Groningen, The Netherlands; |
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Abstract: | The purpose of this study was to identify clinical and laboratory parameters that may improve the effectiveness of the use
of fluorodeoxyglucose positron emission tomography (18 F-FDG PET)(/CT) for diagnosing large vessel vasculitis (LVV), and secondarily to assess the contribution of 18 F-FDG PET/CT in finding other diagnoses for patients without signs of LVV on the scan. A multicenter retrospective study
of 18 F-FDG PET(/CT) scans performed between January 2000 and December 2009 for clinical suspicion of LVV was conducted. A total
of 304 18 F-FDG PET(/CT) scans were included, of which 62 (20%) were positive and 242 (80%) were negative for LVV. Univariate analysis
showed that patients with a positive scan were older (65.9 ± 13.4 versus 58.6 ± 16.5 years, p = 0.002), were more frequently female (76% versus 55%, p = 0.002), more often had a history of temporal arteritis (10% versus 3%, p = 0.044), less frequently had artralgia (31% versus 67%, p = 0.000), and had higher thrombocyte counts (434 ± 161 versus 373 ± 168 × 109/l, p = 0.049) and a higher erythrocyte sedimentation rate (ESR) (72.6 ± 31.0 versus 51.4 ± 30.5 mm/h, p = 0.001) than patients with a negative scan. In the multivariate analysis, only artralgia (OR 0.091; 95% CI 0.023–0.366)
and ESR (OR 1.024; 95% CI 1.002–1.046) remained statistically significant predictors. The presence of artralgia is a statistically
significant negative predictor and an elevated ESR a statistically significant positive predictor of LVV showing up on 18 F-FDG PET(/CT). A reliable prediction of the outcome of the scan, based on these two parameters, is not possible however.
18 F-FDG PET(/CT) allows early diagnosis of LVV and may discover occult inflammatory or neoplastic disorders. |
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