干脏B超形态学变化、MMP-2及TIMP-2水平与肝纤维化分期的关系

目的研究慢性乙型肝炎患者肝脏B超形态学改变、血清基质金属蛋白酶-2（MMP-2）及其组织抑制因子水平（TIMP-2）与其肝纤维化程度的关系。方法选择我院收治的76例慢性乙型肝炎患者作为研究对象，对所有观察对象进行B超引导下肝活检及肝组织纤维化分期，B超检查测定门静脉主干、脾静脉宽度及脾脏厚度；使用ELISA检测法检测慢性乙型肝炎患者血清MMP-2和TIMP-2含量，另外选取15例健康成人作为对照，分析MMP-2、TIMP-2与患者肝纤维化程度之间的关系。结果慢性乙型肝炎患者的脾脏厚度、门静脉主干及脾静脉宽度随患者肝纤维化分级的增加而增大：血清MMP-2、TIMP-2水平随肝纤维化程度加重而升高，r值分别为0．805、0．771，P〈0．05。结论肝脏B超形态学改变及血清MMP-2、TIMP-2水平变化对慢性乙型肝炎患者早期肝纤维化的诊断具有重要意义。

Association of B-type ultrasonographic manifestation, serum MMP-2 and TIMP-2 levels with hepatic fibrosis staging in patients with chronic hepatitis

Objective To study the patients with chronic hepatitis B liver B ultrasonic morphology change, serum ma- trix metalloproteinase-2 （MMP-2） and its organization inhibitory factor levels （TIMP-2） and the relationship between the degree of liver fibrosis. Methods There were 76 cases chronic hepatitis B patients as the research object, the ob- ject of all observed B uhrasonic guided liver biopsy and liver tissue fibrosis stage, B ultrasonic inspection measure- ment of partal vein, spleen vein width level spleen thickness; Used ELISA method detection chronic hepatitis b pa- tients serum MMP-2 and TIMP-2 content, in addition selected 15 cases of healthy adults as a comparison, analyzed the MMP-2, TIMP-2 patients with liver fibrosis and the relationship between the degree. Results Chronic hepatitis patients opposite the spleen thickness, the main portal vein and splenic vein width with hepatic fibrosis in patients with hierarchical increases; Serum MMP-2, TIMP-2 with the level of liver fibrosis degree aggravate and increases, r valuee were 0.805, 0.771, P 〈 0.05. Conclusion Liver B ultrasonic morphology change and serum MMP-2, TIMP-2 level change on chronic hepatitis B patients early diagnosis of hepatic fibrosis has important significance.