Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands |
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| Authors: | Marie Laronze-Cochard, Young-Min Kim, Bertrand Brassart, Jean-Fran ois Riou, Jean-Yves Laronze,Janos Sapi |
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| Affiliation: | Marie Laronze-Cochard, Young-Min Kim, Bertrand Brassart, Jean-François Riou, Jean-Yves Laronze,Janos Sapi, |
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| Abstract: | Several 4,5-bis(dialkylaminoalkyl)-substituted acridines have been prepared starting from acridine and their telomeric G-quadruplex stabilizing properties were evaluated using FRET melting and TRAP (Telomerase Repeat Amplification Protocol Assay) experiments. |
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| Keywords: | Telomere G-quadruplex ligand 4,5-Disubstituted acridine |
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