| 粒细胞-巨噬细胞集落刺激因子与神经保护 |
| |
| 引用本文： | 姜永军,徐格林,刘新峰,LIU Xin-feng. 粒细胞-巨噬细胞集落刺激因子与神经保护[J]. 国际脑血管病杂志, 2009, 17(4). DOI: 10.3760/cma.j.issn.1673-4165.2009.04.012 |
| |
| 作者姓名： | 姜永军 徐格林 刘新峰 LIU Xin-feng |
| |
| 作者单位： | 南京军区南京总医院;南京军区南京总医院;南京军区南京总医院 |
| |
| 摘 要： | 粒细胞-巨噬细胞集落刺激因子(granulocyte-macrophage clony-stimulating factor,GM-CSF)是一种血液细胞因子,与粒细胞和巨噬细胞生成有关.最近的研究提示,脑缺血后GM-CSF在神经系统的表达增高,提示其在脑缺血后神经保护中起着重要作用.GM-CSF主要是通过抗凋亡、促进侧支循环和抑制能量消耗来保护神经元.
|
| 关 键 词： | 粒细胞巨噬细胞集落刺激因子 脑缺血 神经保护药 |
Granolocyte-macrophage clony-stimulating factor and neuroprotection |
| |
| JIANG Yong-jun,ZHOU Zhi-ming,XU Ge-lin,LIU Xin-feng. Granolocyte-macrophage clony-stimulating factor and neuroprotection[J]. International Journal of Cerebrovascular Diseases, 2009, 17(4). DOI: 10.3760/cma.j.issn.1673-4165.2009.04.012 |
| |
| Authors: | JIANG Yong-jun ZHOU Zhi-ming XU Ge-lin LIU Xin-feng |
| |
| Abstract: | Granolocyte-macrophage clony-stimulating factor (GM-CSF) is a heamato-poietic growth factors involved in the generation of granulocytes and macrophages. Recent studies have suggested that the expression of GM-CSF increases following cerebral ischemia in the nervous system, indicating that GM-CSF may play an important role in the neuroprotection after ischemia. M-CSF protects neurons mainly through anti-apoptosis, promoting collateral circulation, and inhibiting energy consumption. |
| |
| Keywords: | grannlocyte-macrophage colony-stimulating factor cerebral ischemia neuroprotective agents |
| 本文献已被 万方数据 等数据库收录！ |
|
