| 血管内皮细胞损伤在家兔多器官衰竭发病过程中的病理意义 |
| |
| 引用本文： | 魏树均,张莉,夏红天,郑成贵,卢立军,刘昌顺. 血管内皮细胞损伤在家兔多器官衰竭发病过程中的病理意义[J]. 微循环学杂志, 1993, 3(3): 1-5,F003 |
| |
| 作者姓名： | 魏树均 张莉 夏红天 郑成贵 卢立军 刘昌顺 |
| |
| 作者单位： | 中国人民解放军北京医学高等专科学校病理教研室 100071 |
| |
| 摘 要： | 利用家兔多器官衰竭(MOF)模型,从形态和机能两方面结合观察了血管内皮细胞的变化。结果平铺切片和电镜观察均显示MOF家兔的血管内皮细胞受到明显损伤。血浆Fn含量锐减,而ⅧR:Ag含量却明显增加,其72h值与实验前比、与对照组比均有显著差异(P<0.05);血浆TXB_2含量随时间明显增加,而6—酮—PGF_(1a)含量则明显下降,故二者的平衡失调。提示内皮细胞损伤在MOF发病过程中可能是重要环节,由此引起的种种变化可能是机体微血栓形成、微循环障碍和器官功能障碍的病理基础之一。
|
| 关 键 词： | 多器官衰竭 家兔 内皮细胞 |
Pathologic Significance of Injury of Vascular Endothelial Cell During Rabbit MOF |
| |
| Wei Shujun,et al. Pathologic Significance of Injury of Vascular Endothelial Cell During Rabbit MOF[J]. Chinese Journal of Microcirculation, 1993, 3(3): 1-5,F003 |
| |
| Authors: | Wei Shujun et al |
| |
| Abstract: | The moddle of rabbit Multi-organ-failure(MOF) was used in the experiment and the changes of endothelial cell about shape and function were observed. Both hautchen and electromicroscope showed that endothelial cell was injured apparently. The content of plasma Fn decreases suddenly, meanwhile, the ⅧR: Ag increases evidently with the passage of time and the latter decreases, which shows the injury of the endothelial cell is an important link in MOF. The changes caused by the injury of endothelial cell probably are one of pathologic bases on microthrombosis, the obstruction of microcirculation and organ failure. |
| |
| Keywords: | Multi-organ-failure Rabbit Endothelial cell |
| 本文献已被 CNKI 等数据库收录！ |
|
