ICAM-1、MMP-9在人脑胶质瘤的表达及相关性研究

目的 探讨细胞间黏附分子-1（ICAM-1）、基质金属蛋白酶-9（MMP-9）在人脑胶质瘤的表达及相关性研究。方法 采用免疫组织化学法检测82例胶质瘤组织中ICAM-1、MMP-9的表达水平。结果 ICAM-1在82例人脑胶质瘤蜡块组织中全部呈阳性表达，72例MMP-9呈阳性表达，阳性率87，80％，实验对照为脑外伤手术减压的脑组织11例未见ICAM-1、MMP-9表达。ICAM-1、MMP-9阳性表达水平在胶质瘤高度恶性组高于低度恶性组，差别有显著性意义（P＜0．01）。ICAM-1和MMP-9在人脑胶质瘤的表达存在相关性（r=0．436）。结论 ICAM-1和MMP-9在胶质瘤存在协同作用，共同参与胶质瘤的发生、发展和恶性演变，并由此推测ICAM-1与MMP-9联合检测会更好地对脑胶质瘤的恶性生物学行为进行评价和判断。

Study on expression and correlation between ICAM-1 and MMP-9 in human glioma

Objective To study the expression and correlation between intercellular adhesion molecule-1 (ICAM-1) and matrix metalloproteinase-9 (MMP-9) in human glioma. Methods The expression of ICAM-1 and MMP-9 in 82 samples of glioma was detected immunohistochemically. Results The expression of ICAM-1 in all of the 82 samples was positive, and the positive rate was 100%. The expression of MMP-9 in the 72 samples of glioma was positive, and the positive rate was 87.80%. In the control group consisting of 11 samples of brain tissue of cerebral trauma after decompressive surgery, there was no ICAM-1 and MMP-9 expression. The positive level of high-grade malignant glioma is higher than that of low-grade malignant glioma (P<0.01). There was correlation in the expression between ICAM-1 and MMP-9 (r=0.436). Conclusion ICAM-1 and MMP-9 may play a synergistic role in the occurrence, development and malignance in glioma. Hence, it is a better way to estimate and judge the malignant biological behavior of glioma by combined detection of ICAM-1 and MMP-9.