| 钠/钙和钠/氢交换蛋白与心肌缺血再灌注损伤 |
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| 引用本文： | 王雅锋,方秋娟. 钠/钙和钠/氢交换蛋白与心肌缺血再灌注损伤[J]. 医学综述, 2007, 13(5): 368-370 |
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| 作者姓名： | 王雅锋 方秋娟 |
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| 作者单位： | 福建医科大学基础医学院生理与病理生理学系,福州,350004 |
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| 摘 要： | Ca2+超载与缺血/再灌注损伤有密切关系,钠/钙交换蛋白和钠/氢交换蛋白是缺血/再灌注Ca2+超载过程中两个至关重要的因素。目前已有很多钠/钙交换蛋白(NCX)抑制剂和钠/氢交换蛋白(NHE)抑制剂用来防止Ca2+超载引起的缺血再灌注损伤。
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| 关 键 词： | 心肌缺血再灌注损伤 钙超载 Na~+/Ca~(2+)交换蛋白 质子 抑制剂 |
| 文章编号： | 1006-2084（2007）05-0368-03 |
| 收稿时间： | 2006-08-04 |
| 修稿时间： | 2007-02-02 |
Exchanger of Na+/Ca2+ and Na+/H+ and Myocardial Ischemical Reperfusion Injury |
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| WANG Ya-feng,FANG Qiu-juan. Exchanger of Na+/Ca2+ and Na+/H+ and Myocardial Ischemical Reperfusion Injury[J]. Medical Recapitulate, 2007, 13(5): 368-370 |
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| Authors: | WANG Ya-feng FANG Qiu-juan |
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| Affiliation: | Department of Physiology and Pathophysiology , Fujian Medical University, Fuzhou 350004, China |
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| Abstract: | Ca~(2 ) overload is closely related to ischemia/reperfusion injury,Exchangers of Na /Ca~(2 ) and Na /H are two critical factors during Ca~(2 ) overload resulting from ischemia/reperfusion.At present,many inhibitors of Na~ /Ca~(2 ) exchanger and Na /H exchanger were developed to prevent ischemia/reperfusion injury induced by Ca~2 overload. |
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| Keywords: | Ischemia/reperfusion injury Ca~(2 ) overload Na /Ca~2 exchanger Proton Inhibitor |
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