Survivin在分化型甲状腺癌组织中的表达及其与肿瘤微血管形成的关系

目的：探讨分化型甲状腺癌组织中Survivin表达与肿瘤微血管形成的关系。方法：采用免疫组织化学方法，对47例分化型甲状腺癌、10例甲状腺腺瘤、10例正常甲状腺组织进行Survivin和血管内皮生长因子（VEGF）检测，并应用病理图像分析系统测定其含量；计数微血管密度（MVD）。结果：47例分化型甲状腺癌中Survivin蛋白的阳性表达率为46．8％，甲状腺腺瘤和正常甲状腺组织中均为阴性表达。分化型甲状腺癌中Survivin蛋白表达与VEGF蛋白表达和MVD计数均具有显著相关性（均P〈O．05）；与肿瘤临床分期、肿瘤包膜完整与否及颈部淋巴结转移密切相关。结论：Survivin在分化型甲状腺癌组织中表达上调，并与肿瘤微血管生成关系密切，提示Survivin在分化型甲状腺癌的发生、发展中起重要作用。

Expression of Survivin and its correlation with tumor angiogenesis in differentiated thyroid carcinomas

Objective:To identify the expression of Survivin and its relationship with tumor angiogenesis in differentiated thyroid carcinomas.Method:The expression of Survivin, VEGF and MVD were detected by immunohistochemical staining (SP methods) in 47 differentiated thyroid carcinomas,10 thyroid adenoma and 10 normal thyroid tissues and their content were measured by pathological image analysis system.Result:The expression of Survivin and VEGF in differentiated thyroid carcinomas was 46.8% and 61.7%, respectively. No expression of Survivin was detected in thyroid adenoma and normal thyroid tissues. The expression of Survivin was significantly correlated with the expression of VEGF and MVD in differentiated thyroid carcinomas. The expression of Survivin was significantly associated with clinical stages, tumor complete capsulae and lymph node metastasis.Conclusion:The up-regulation of Survivin expression and its close relationship with angiogenesis may play an important role in carcinogenesis and development of differentiated thyroid carcinomas.