危重症患儿血清脂肪酸构成的临床研究

目的 探讨危重症患儿血清游离脂肪酸构成及含量的变化.方法 采用气相色谱法测定27例危重症患儿和34例健康儿的血清游离脂肪酸谱,比较健康儿、危重症患儿恢复前后的血清游离脂肪酸谱的改变.结果 危重症阶段,血清中棕榈酸、棕榈油酸、油酸、山嵛酸、花生四烯酸及二十碳五烯酸的含量较健康者明显增高(P＜0.05);危重症抢救成功者恢复两周后,血清中豆蔻酸、棕榈酸、棕榈油酸、油酸、花生酸的含量较健康者明显增高(P＜0.05).结论 危重症阶段及危重症抢救成功者恢复后,患儿血清游离脂肪酸谱有变化;危重症的严重应激状态影响血清游离脂肪酸的构成及含量.

Changes of serum free fatty acid profile in children with critical illness

Objective To investigate the changes of composition and level of serum free fatty acid (FFA)of children with critical illness.Methods The serum FFAs were measured by gas chromatography in 61 children(27 critically ill eases and 34 healthy controls).The changes in serum FFA was compared between healthy children and critically ill cases.We also evaluated the difference between the data before treatment and those after recovery in children with critical illness.Results Levels of palmitic acid,palmitoleic acid.oleic acid,docosanoic acid.arachidonic acid(AA)and eicosapentaenoic acid(EPA)were evidently higher in the critically ill children than those of healthy control(P＜0.05);children underthe recovery stage showed higher levels of myristic acid,palmitic acid,palmitoleic acid,oleic acid,arechidic acid as compared with healthy controis(P＜0.05).Conclusion Compexed with healthy children,the profile of serum FFA was quite different in critically ill and recovery ones.Critical illness may influence the profile of serum FFA.