急性有机磷农药中毒患者血清前白蛋白和透明质酸的变化

目的探讨血清前白蛋白(Prealbumin,PAB)和透明质酸(hyaluronicacid,HA)在急性有机磷农药中毒患者中的变化及临床意义。方法将83例急性有机磷农药中毒(acuteorganophosphoruspesticide poisoning,AOPP)患者分成轻度中毒组、中度中毒组和重度中毒组3组,另选取30例健康人为正常对照组,各组均采用免疫散射比浊法检测血浆PBA的含量,应用放射免疫法检测血浆HA含量。结果AOPP轻度中毒组患者血清PAB、HA含量与正常对照组比较,有非常显著性差异(P<0.01),而常规肝功能指标AST、ALT、总胆红素、总蛋白、白蛋白与正常组比较,差异无显著性(P>0.05);随着中毒程度的加重,HA含量、AST、ALT、总胆红素逐渐上升,血清PAB逐渐下降。结论AOPP患者血清PAB和HA含量的变化可作为反映AOPP肝功能损害的敏感指标,而且在一定程度上可作为反映AOPP病情轻重的指标。这对及时调整治疗方案,防治肝脏损害的发生、发展有重要临床意义。

Change of serum prealbumin and hyaluronic acid in patients with acute organophosphorus pesticide poisoning

Objective To investigate the change of plasma prealbumin(PAB) and serum hyaluronic acid(HA) in patients with acute organophosphorus pesticide poisoning(AOPP). Methods Serum HA and plasma PAB were measured in 83 patients with AOPP and compared with 30 healthy controls.The 83 patients were divided into slight poisoning group, moderate poisoning group and server poisoning group. Results There were difference in plasma PBA and serum HA between slight poisoning group and controls. But the conventionality liver function index, alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin (TBIL), total protein(TB), albumin(ALB) was not significantly different compared with controls (P>0.05).Serum HA, AST, ALT, TBIL were gradually increased and plasma PBA was decreased with the degree of poisoning. Conclusion Plasma PBA and serum HA are sensitive index of the liver damage with AOPP,and can serve as an index for judging AOPP. It is important in changing cure plan and preventing liver damage cause.