1976~1990年北京地区腺病毒肺炎的流行特点及分子流行病学研究

对１９７６～１９９０年度１５个冬春２７５７例住院肺炎患儿作了病毒学检查，并对８０～９０年代及部分５０、６０年代分离的３、７型腺病毒（Ａｄ３、Ａｄ７）９９株用１２种ＤＮＡ限制性内切酶作了基因组型分析。研究结果阐明了北京地区腺佟毒（Ａｄｖ）肺炎的流行特点。１９７６年以来北京地区没有出现Ａｄｖ肺炎的爆发流行，仅有小规模的流行。Ａｄ３、Ａｄ７仍是Ａｄｖ肺炎的主要病原，但在不同阶段以一个血清型为主。１９８２

Epidemiolog of Adenovirus Pneumonia in Beijing, 1976~1990

From 1976 to 1990 for 15 consecutive epidemic years, virological examinations were carried out on 2757 hospitalized infants and children infected with pneumonia. Ninety-nine strains of types 8 and 7 adenovirus (Ad3, Ad7) isolated from 50s to 90s were analyzed with 12 DNA restriction endonucleases. Results showed the epidemiologic characteristics of adenovirus (Adv) pneumonia in Beijing. Epidemic occurred yearly, but there was no severe outbreak of Adv pneumonia as in 1958. Ad3 and Ad7 were the main etiologic agents of Adv pneumonia. Ad7 was dominant in 1976~1980; while Ad3 was more prevalent in 1981~1990. DNA restriction endonuclease analysis revealed six genome types of Ad7 and three genotypes of Ad3. 7a1, 7a4, 7b and 7g occurred in 1958, 1965, but disappeared between 1980~1990; 3a2 was first detected in 1962. From 1980 to 1990, 7d and 3a2 were the dominant genome types. Among the Ad7 strains only one strain of 7d1 was identified; all others were 7d. 3a4 and 3a6 first appeared in 1984 and 1986, respectively. The changes of epidemic patterns seemed correlated with the variations of genome types.