HBV、HCV感染与HCC发生关系的病因学研究

应用启东肝癌高发区的调查资料和血清检验资料，对乙肝病毒（ＨＢＶ）、丙肝病毒（ＨＣＶ）感染与原发性肝细胞型肿癌（ＨＣＣ）的关系进行了病因学研究。结果显示：１１０例ＨＣＣ中，ＨＢＶ、ＨＣＶ的流行率分别为８５．４５％和１７．２７％，显著高于对照的５０．４５％和４．０９％，单因素及多元条件Ｌｏｇｉｓ─ｔｉＣ回归分析均显示ＨＢＶ感染指标ＨＢｓＡｇ、Ｐｒｅ─Ｓ２蛋白和ＨＣＶ感染指标抗－ＨＣＶ为ＨＣＣ的重要危险因素，ＯＲ值分别为１０．２２、２．９６和２．６８，饮茶为唯一的保护因素，ＯＲ值为０．３６．ＨＢＶ与ＨＣＶ同时感染引起ＨＣＣ发生的ＯＲ值校高为６．４８，ＨＢＶ、ＨＣＶ分别感染的ＯＲ值相似，分别为３．９０和３．８９，但由于启东人群ＨＢＶ的感染率较高，其引起ＨＣＣ的归因危险度最高，为启东ＨＣＣ的首要病因，ＨＣＶ也有相当的病因作用，此外尚有ｌｌ．８２％的病例可能由其它环境或遗传因素引起。

Etiologic Study on the Relationship between HBV, HCV and HCC

A total of 110 HCC patients were. sampled randomly in 20townships of Qidong county (a higher incidence area of HCC in China) from Mar. to Sept. 1989. Each patient was paired with two healthy persons as control. The results showed that the prevalences of HBV and HCV in 110 patients were 85.45% and 17.27% respectively, and were significantly higher than that in control (50.45% and 4.09%). Using Conditional Logistic Regression Model. we found that the main risk factors of HCC in Qidong were HBsAg and Pre-S₂ for HBV and anti-HCV for HCV. The OR value were 10.22, 2.96 and 2.63, respectively. Drinking tea was the only protective factor (OR=0.36). Among 110 HCC patients. 13.64% were positive for both HBV and HCV. The OR value was the highest (6.48). 88.18% patients were either HBV or HCV positive. The OR values were similiar (3.90 and 3.89). It suggests that the most important risk factor of HCC in Qidong was HBV infection because it had a higher prevalence among the population while the HCV infection having an equal OR value was also a risk factor.