Distinct cytokine and chemokine profiles in the aqueous of patients with uveitis and cystoid macular edema |
| |
Authors: | van Kooij Bram Rothova Aniki Rijkers Ger T de Groot-Mijnes Jolanda D F |
| |
Affiliation: | F. C. Donders Institute of Ophthalmology, Utrecht, The Netherlands. b.vankooij@oogh.azu.nl |
| |
Abstract: | PURPOSE: To investigate the global cytokine and chemokine expression pattern in the aqueous humor of uveitis patients and relate them to clinical features. DESIGN: Cross-sectional study. METHODS: In 31 aqueous humor samples from uveitis patients, the concentration of mediators was measured by a multiplex immunoassay. Eleven control samples were included. RESULTS: Uveitis samples had higher levels of interleukin-6, interleukin-8, soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule (sVCAM), and interferon-inducible protein-10 (IP-10) than nonuveitis controls. Active uveitis samples had higher levels of interleukin-6, interleukin-10, interferon-gamma, sVCAM, regulated on activation, normal T cell expressed and secreted (RANTES), and IP-10 than quiescent uveitis samples. Infectious uveitis was associated with higher levels of interleukin-10 than noninfectious uveitis (P < .03 for all subgroups). No significant differences were found between cystoid macular edema (CME) and non-CME samples. CONCLUSIONS: Elevated levels of specific mediators were found in active and in infectious uveitis, but not in CME. Mediator profiles might lead to a better understanding of the pathogenesis of uveitis. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|