Prognostic impact of dimensional factors in pT1 gastric cancer |
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| Affiliation: | 1. Liver Intensive Care Unit, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Birmingham, UK;2. Birmingham Liver Failure Research Group, Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK;3. Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK;4. Department of Cellular Pathology, QEHB, Mindelsohn Way, Birmingham, UK;5. Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK;6. Liver Unit, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Birmingham, UK;7. Institute for Liver and Digestive Health, Royal Free Campus, UCL, London, UK;8. Institute of Hepatology, Foundation for Liver Research, London, UK;1. Central Interdisciplinary Endoscopy Department, Mannheim University Hospital, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany;2. Surgery Department, Karlsruhe Municipal Hospital, Moltkestrasse 90, 76133, Karlsruhe, Germany;1. School of Clinical Medicine, Tsinghua University, Beijing 100084, China;2. Department of Neurosurgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China;3. Department of Neurosurgery, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China |
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| Abstract: | BackgroundThe significance of the dimensional factors (tumor diameter, area and volume) as the prognostic factor has not been precisely evaluated in pT1 gastric cancer.ObjectivesThis study aimed to identify the clinical impact and to confirm the clinical feasibility of the dimensional factors as prognostic factors in pT1 gastric cancer.MethodsWe analyzed prognostic factors for disease-specific survival (DSS), overall survival (OS) using clinicopathological factors by univariate and multivariate analyses and the pattern of recurrence in 2011 pT1 gastric cancer (mucosal and submucosal cancers) undergoing R0 gastrectomy. The cut-off values of each dimensional factor was decided by the ROC curve.ResultsCox proportional hazard regression model showed that older age (≥75) and more advanced pN stage were adverse independent prognostic factors for DSS, and revealed that older age (≥75), greater preoperative co-morbid diseases, proximal and total gastrectomy, operative method and Clavien-Dindo classification (≥grade III) were independent adverse factors for OS. Any dimensional factors were not independent prognostic factors for any survival.ConclusionsThe dimensional factors do not influence both OS and DSS in pT1 gastric cancer patients and so it is difficult to apply these dimensional factors for conducting therapeutic strategies. |
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| Keywords: | Tumor diameter Tumor area Tumor volume pT1 gastric cancer Prognostic factor |
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