Outcomes of the endoscopic endonasal approach for tumors in the third ventricle or invading the third ventricle |
| |
| Affiliation: | 1. Department of Neurosurgery, Yeungnam University Hospital, Daegu, Republic of Korea;2. Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea;3. Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea;4. Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;5. Department of Neurosurgery, Chungbuk National University, College of Medicine, Cheongju, Republic of Korea;1. Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA;2. Sylvester Comprehensive Cancer Center, University of Miami Health System, Miami, Florida, USA;3. Department of Neurosurgery, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA;1. Department of Neurosciences, Reproductive and Odontostomatological Sciences, Division of Neurosurgery – Università degli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy;2. Department of Clinical Medicine and Surgery, Section of Infectious Diseases – Universitàdegli Studi di Napoli Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy;3. Department of Neurosciences, Division of Neurosurgery – Università degli Studi di Messina, Messina, Italy;1. Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;2. Department of Otorhinolaryngology−Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;1. Department of Neurosurgery, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, China;2. Harvard Medical School, 25 Shattuck Street, Boston, MA, USA;1. Department of Hypothalamic and Pituitary Surgery, Toranomon Hospital, Tokyo, Japan;2. Okinaka Memorial Institute for Medical Research, Tokyo, Japan;1. Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK;2. Imperial College London, Charing Cross Hospital, London, UK |
| |
| Abstract: | We aimed to retrospectively analyze the surgical and clinical outcomes of the endoscopic endonasal approach (EEA) for tumors in the third ventricle or invading the third ventricle. In total, 82 patients who had undergone surgical treatment using the EEA for tumors involving the third ventricle were enrolled in this study. This cohort study comprised 46 male and 36 female patients. The median age was 37 years (range, 5–76), and the median follow-up duration was 56.5 months (range, 6–117). Seventy-six patients had craniopharyngiomas, and 6 had gangliocytomas, gangliogliomas, astrocytomas, diffuse midline gliomas and lymphomas. Gross total removal was performed in 71 (86.5%) of the 82 patients, subtotal tumor removal in 7 patients and partial removal or biopsy in 4 patients. The pituitary stalk was preserved in 20 cases. Visual function improved in 40 (81.6%) of 49 patients. Endocrine function worsened in 41 (50%) of 82 patients. Hypothalamic function improved in 16 (72.7%) of 22 cases. Postoperative obesity occurred in 3 (20.0%) of 15 children and 11 (23.9%) of 46 adult patients. The postoperative cerebrospinal fluid leakage rate was 3.6%. Postoperative meningitis occurred in 18 (21.9%) cases. Permanent diabetes insipidus was identified in 73 (89.0%) of 82 patients. Tumor recurrence was observed in 10 patients (12%). The EEA appears to be a safe and effective treatment modality for tumors in the third ventricle or involving the third ventricle. However, more cases and long-term follow-up outcomes are required to confirm the clinical efficacy of the EEA. |
| |
| Keywords: | Intraventricular Third ventricle Endoscopic Pituitary surgery Craniopharyngioma Outcome |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
