Cerebellar anaplastic astrocytoma in adult patients: 15 consecutive cases from a single institution and literature review |
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| Institution: | 1. Burdenko Neurosurgery Center, Moscow, Russia Federation;2. Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London, United Kingdom;1. Department of Otolaryngology–Head and Neck Surgery, University of California, Irvine, Orange, CA, USA;2. Medical Scientist Training Program, University of Pittsburgh and Carnegie Mellon University, Pittsburgh, PA, USA;3. Department of Neurological Surgery, University of California, Irvine, Orange, CA, USA;1. Vascular Surgery, Department of Surgery and Morphological Sciences, University of Insubria School of Medicine, Circolo University Hospital, Varese, Italy;2. Interventional Radiology, and Department of Surgery and Morphological Sciences, University of Insubria School of Medicine, Circolo University Hospital, Varese, Italy;3. Anesthesia and Palliative Care, Circolo University Hospital, Varese, Italy;1. Department of Obstetrics & Gynecologic, West China Second University Hospital, Sichuan University, Chengdu, China;2. Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China;3. Division of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, China;4. West China Biomedical Big Data Center, Sichuan University, Chengdu, China;5. Department of Diagnostic Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, China;6. Department of Neurosurgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People''s Hospital, School of Medicine, University of Electronic Science and Technology of China, China;1. Haseki Research and Training Hospital, Neurosurgery Clinic, Istanbul, Turkey;2. Istinye University, Neurosurgery Clinic, Istanbul, Turkey;3. Department of Pathology, Medical School, Yeditepe University, Istanbul, Turkey;4. Memorial Hospital, Neurosurgery Clinic, Ankara, Turkey;1. Department of Neurosurgery, Queensland Children’s Hospital, Brisbane, Australia;2. School of Clinical Medicine, University of Queensland, Brisbane, Australia;3. Academic Department of Neurosurgery, Addenbrooke’s Hospital, Cambridge, United Kingdom;4. QCIF Facility for Advanced Bioinformatics, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia |
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| Abstract: | Adult cerebellar anaplastic astrocytomas (cAA) are rare entities and their clinical and genetic appearances are still ill defined. Previously, malignant gliomas of the cerebellum were combined and reviewed together (cAA and cerebellar glioblastomas (cGB), that could have possibly affected overall survival (OS) and progression-free survival (PFS). We present characteristics of 15 adult patients with cAA and compared them to a series of 45 patients with a supratentorial AA (sAA) in order to elicit the effect of tumor location on OS and PFS. The mean age at cAA diagnosis was 39.3 years (range 19–72). A history of neurofibromatosis type I was noted in 1 patient (6.7%). An IDH-1 mutation was identified in 6/15 cases and a methylated MGMT promoter in 5/15 cases. Patients in study and control groups were matched in age, sex and IDH-1 mutation status. Patients in a study group tended to present with longer overall survival (50 vs. 36.5 months), but the difference did not reach statistical significance. In both cAA and supratentorial AA groups presence of the IDH-1 mutation remains a positive predictor for the prolonged survival. The present study suggests that adult cAA constitute a group of gliomas with relatively higher rate of IDH-1 mutations and prognosis similar to supratentorial AA. The present study is the first to systematically compare cAA and supratentorial AA with respect to their genetic characteristics and suggests that both groups show a similar survival prognosis. |
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| Keywords: | Cerebellar anaplastic astrocytoma IDH-1 mutation MGMT methylation Multifocal glioma |
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