Association of serum levels and receptor genes BsmI,TaqI and FokI polymorphisms of vitamin D with the severity of multiple sclerosis |
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| Affiliation: | 1. Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran;2. Department of Immunology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran;3. Department of Immunology, Molecular and Cell Biology Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran;1. Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA;2. Department of Neurosurgery, Rhode Island Hospital, Providence, Rhode Island, USA;1. Neurology Department, Soroka University Medical Center, Beer-Sheva, Israel;2. Radiology Institute, Soroka University Medical Center, Beer-Sheva, Israel;3. Research Institute, Soroka University Medical Center, Beer-Sheva, Israel;1. Department of Head and Neck Surgery, Ronald Reagan UCLA Medical Center, Los Angeles, CA, United States;2. Department of Neurosurgery, Ronald Reagan UCLA Medical Center, Los Angeles, CA, United States;3. UCLA Jonsson Comprehensive Cancer Center, Ronald Reagan UCLA Medical Center, Los Angeles, CA, United States;4. Department of Radiology, Ronald Reagan UCLA Medical Center, Los Angeles, CA, United States;5. Office of the Patient Experience, Ronald Reagan UCLA Medical Center, Los Angeles, CA, United States;6. Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA, United States;1. MedStar Georgetown University Hospital, Department of Neurosurgery, 3800 Reservoir Road NW, 7PHC, Washington, DC 20007, USA;2. MedStar Georgetown University Hospital, Department of Neurology, 3800 Reservoir Road NW, 7PHC, Washington, DC 20007, USA;1. Medical-Surgical Research Center, University of Cartagena, Cartagena, Colombia;2. Neurosurgeon-Critical Care, Biomedical Research Center, University of Cartagena, Cartagena de Indias, Colombia;3. Department of Neurosurgery, All India Institute of Medical Sciences, India;1. Spine Center, Department of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, PR China;2. Peking University Third Hospital Intervention and Vascular Surgery, N0.38 Xueyuan Road, Beijing 100083, China |
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| Abstract: | PurposeMultiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease. Vitamin D has a major role in preventing inflammatory disorders. Therefore, any alteration in vitamin D receptor (VDR) might be a genetic risk factor for MS development. This study aimed to evaluate the effect of serum levels and VDR FokI, BsmI, and TaqI gene polymorphisms on the severity of MS.MethodsThis case-control study recruited 160 MS patients (71.9% females, mean age of 34.3 ± 8.3 years) and 162 (66.7% females, mean age 35.4 ± 7.9 year) age, sex, and ethnicity matched healthy controls. FokI (rs2228570), BsmI (rs1544410), and TaqI (rs731236) polymorphisms were carried out using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Demographic, clinical parameters, and the levels of vitamin D were compared between groups.ResultsWe found that the frequency of FokI and TaqI polymorphisms significantly differed between the patients and the controls (p = 0.0127 and p = 0.0236, respectively). The MS patients had low levels of vitamin D compared to the controls (p = 0.011). In addition, TaqI T/C polymorphism significantly decreased the levels of vitamin D in the MS patients (p = 0.002). However, there was no significant association between FokI or BsmI SNPs and the levels of vitamin D in MS patients (p > 0.5).ConclusionOur results suggest that FokI and TaqI polymorphisms of VDR are associated with MS risk and TaqI polymorphism is associated with Vitamin D levels in MS patients. Meanwhile, no difference was observed between VDR gene polymorphisms and any types of MS. |
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| Keywords: | Multiple sclerosis Vitamin D Vitamin D receptor TaqI FokI BsmI |
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