Predictors of thermal response and lesion size in patients undergoing magnetic resonance-guided focused ultrasound thalamotomy |
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| Affiliation: | 1. Department of Neurosurgery, St Vincent’s Hospital, Darlinghurst, NSW, Australia;2. Department of Medical Imaging, and Neurology, St Vincent’s Hospital, Darlinghurst, NSW, Australia;3. Department of Neurology, St Vincent’s Hospital, Darlinghurst, NSW, Australia;4. Sydney Neuroimaging Analysis Centre, Camperdown, NSW, Australia;5. School of Medicine, University of New South Wales, Sydney, NSW, Australia;6. Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia;7. Royal Prince Alfred Institute of Academic Surgery, University of Sydney, Camperdown, NSW, Australia;1. Centre Hospitalier Universitaire Vaudois, Neurosurgery Service and Gamma Knife Center, Lausanne, Switzerland;2. Medical Image Analysis Laboratory and Department of Radiology-Center of Biomedical Imaging, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland;3. Signal Processing Laboratory (LTS5), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland;4. Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland;5. Stereotactic and Functional Neurosurgery Service and Gamma Knife Unit, CHU Timone, Marseille, France;6. Neurology Department, CHU Timone, Marseille, France;7. Department of Diagnostic and Interventional Neuroradiology, AMU, CRMBM UMR CNRS 7339, Faculté de Médecine et APHM, Hopital Timone, Marseille, France;8. Centre for Clinical Epidemiology, Institute of Social and Preventive Medicine, Lausanne, Switzerland;9. Department of Radiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland;10. Faculty of Medicine, University of Geneva, Geneva, Switzerland;11. Medical Image Processing Laboratory, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland;1. Department of Biotechnological and Applied Clinical Science, University of L’Aquila AQ, Via Vetoio 1 AQ, 67100, Italy;2. Neurology Unit, San Salvatore Hospital, L''Aquila, Italy;3. Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy;4. Department of Neurosurgery, University of L’Aquila AQ, Via Vetoio 1 AQ, 67100, Italy;1. Department of Emergency Radiology, San Salvatore Hospital, L’Aquila, Italy;2. Second Department of Radiology, University General ATTIKON Hospital Athens, Athens, Greece;3. Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy |
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| Abstract: | Magnetic resonance-guided focused ultrasound (MRgFUS) is being increasingly utilized in the treatment of movement disorders such as essential tremor (ET) and Parkinson’s disease (PD). Whilst skull density ratio (SDR) has previously been correlated with achieving lesional temperature rises, other patient factors such as brain and cerebrospinal fluid (CSF) volume have not previously been investigated. We aimed to investigate the effect of brain and CSF volumes on lesional temperature rises, as well as the effect of brain and CSF volumes and SDR on post-treatment lesion sizes. Fifty-four consecutive patients were studied with patient and treatment-related variables collected along with post-treatment lesion sizes. Linear regression analysis identified that SDR alone was associated with lesional temperatures. Both SDR and brain atrophy were associated with post-treatment lesion sizes on linear regression analysis. On multiple linear regression analysis SDR was significantly associated with post-treatment lesion size, and the association between brain atrophy and lesion sizes approached significance, a finding that warrants further investigation. |
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| Keywords: | MR-guided focused ultrasound SDR Brain atrophy CSF volume Thalamotomy Essential tremor Parkinson’s disease Functional neurosurgery |
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