Epidemiology of paediatric central nervous system tumours in Queensland,Australia |
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| Affiliation: | 1. Department of Neurosurgery, Queensland Children’s Hospital, Brisbane, Australia;2. School of Clinical Medicine, University of Queensland, Brisbane, Australia;3. Academic Department of Neurosurgery, Addenbrooke’s Hospital, Cambridge, United Kingdom;4. QCIF Facility for Advanced Bioinformatics, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia;1. Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;2. Department of Neurosurgery, Mayo Clinic, Rochester, MN 55905, USA;3. Department of Neurosurgery, Zucker School of Medicine at Hofstra, Long Island Jewish Medical Center and North Shore University Hospital, Northwell Health, Manhasset, NY 11030, USA;1. Neurology Department, Vall d’Hebron Universitary Hospital, Barcelona, Spain;2. Cooper Medical School of Rowan University, Camden, USA;1. Department of Orthopaedic Surgery, Good Samsun Hospital, Busan, Republic of Korea;2. Department of Orthopaedic Surgery, Gupo Sungshim Hospital, Busan, Republic of Korea;3. Department of Orthopaedic Surgery, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea;4. Department of Orthopaedic Surgery, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea;1. Department of Biotechnological and Applied Clinical Science, University of L’Aquila AQ, Via Vetoio 1 AQ, 67100, Italy;2. Neurology Unit, San Salvatore Hospital, L''Aquila, Italy;3. Department of Life, Health and Environmental Sciences, University of L’Aquila, Italy;4. Department of Neurosurgery, University of L’Aquila AQ, Via Vetoio 1 AQ, 67100, Italy;1. Umraniye Training and Research Hospital, Department of Neurosurgery, Istanbul, Turkey;2. Taksim Training and Research Hospital, Department of Neurosurgery, Istanbul, Turkey;3. Akdeniz University, School of Medicine, Antalya, Turkey;4. Istanbul Kartal Dr. Lütfi Kırdar Training and Research Hospital, Turkey;5. Acibadem Mehmet Ali Aydinlar University, School of Medicine, Department of Neurosurgery, Istanbul, Turkey;1. Burdenko Neurosurgery Center, Moscow, Russia Federation;2. Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London, United Kingdom |
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| Abstract: | Within Australia, there is little epidemiologic information regarding paediatric central nervous system (CNS) tumours. This study examined the epidemiology of childhood CNS tumours at Queensland Children’s Hospital (QCH), the major paediatric referral centre for Queensland and northern New South Wales. We assessed the data from 221 newly diagnosed childhood CNS tumours across a five-year period from 2015 to 2019. Recurrent tumours were excluded. Data was collected on patient age, gender, histopathological diagnosis, tumour grade, anatomical site, and residential geographical location. The incidence within this period ranged from 2.65 to 3.85 cases per 100,000 children. The median symptom interval was 30 days (IQR 14–122) with presenting features similar to previous studies. The symptom interval was shorter for children zero to three years compared to children four years or older. The most frequent tumour was pilocytic astrocytoma, followed by medulloblastoma and Langerhans cell histiocytosis. The posterior fossa was the most frequent anatomical location for tumours. Our study demonstrated a shorter symptom interval in comparison to previous literature. The study was able to determine the incidence and presenting features within an Australian population. |
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| Keywords: | Epidemiology Paediatric Brain Tumours Australia |
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