Ten year cumulative incidence of dementia after late onset epilepsy of unknown etiology |
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| Affiliation: | 1. Global Brain Health Institute at University of California San Francisco, San Francisco, CA, USA;2. Department of Neurology, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel;3. Cognitive Neurology Clinic, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel;4. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;1. Department of Neurosurgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China;2. Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China;1. Department of Neurosurgery, Cleveland Clinic, Cleveland, OH, United States;2. Department of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, TX, United States;1. Department of Neurosurgery, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia;2. Department of Neurosurgery, George Washington University School of Medicine and Health Sciences, Washington, DC, USA;1. Department of Emergency and Critical Care Medicine, Nippon Medical School Tama Nagayama Hospital, Tokyo, Japan;2. Department of Neurosurgery, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan;3. Department of Neurosurgery, National Hospital Organization Disaster Medical Center, Tokyo, Japan;4. Department of Neurosurgery, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan;5. Department of Neurosurgery, Tokai University Hachioji Hospital, Tokyo, Japan;6. Department of Neurosurgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan;7. Department of Neurology, Musashino Red Cross Hospital, Tokyo, Japan;8. Department of Neurosurgery, Omori Red Cross Hospital, Tokyo, Japan;9. Department of Neurosurgery, Kyorin University, Tokyo, Japan;10. Department of Stroke and Cerebrovascular Medicine, Kyorin University, Tokyo, Japan;1. University of Hawai’i at Mānoa, John A. Burns School of Medicine, Honolulu, HI, USA;2. University College London, Queen Square Institute of Neurology, London, UK;3. University of Queensland, Faculty of Medicine, Brisbane, Australia;4. University of Iowa, Carver College of Medicine, Iowa City, Iowa, USA;5. Universidad Internacional del Ecuador, Escuela de Medicina, Quito, Ecuador |
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| Abstract: | Recent epidemiological studies suggest late life onset epilepsy of unknown etiology (LOEU) is a risk factor for future dementia. These studies rely on inclusion and exclusion of multiple diagnostic codes rather than structured data and neuroimaging findings, and thus challenging to interpret clinically. We assessed the cumulative incidence of dementia in patients with LOEU diagnosed through admission data and neuroimaging over a 10-year follow-up and compared baseline characteristics that distinguish group level incident dementia. We screened our hospital records for patients aged 55–69 with new epilepsy, admitted between 2000 and 2008, and excluded patients diagnosed with epilepsy from an underlying cause on medical records or neuroimaging. We used retrospective hospital data to follow patients for incident dementia or mortality at 10 years and compared baseline (demographics, depression or anxiety, vascular risk factors, results of electroencephalogram (EEG) studies, antidepressant use and type of ant seizure medication) and follow up (seizure recurrence, incident cerebrovascular disease) characteristics for patients with and without incident dementia.Fifty-four LOEU cases were screened, age at first seizure was 61 ± 5. The 10-year cumulative incidence of dementia was 22.20% (95% Confidence Interval 22.08–23.10%) and time to dementia diagnosis was 5.4 ± 3.9 years. Patients with incident dementia were more likely to be women (83% vs 38%, p = 0.002), have interictal epileptic form discharges (IED) on baseline EEG (70% vs 29%, p = 0.011) and depression or anxiety (50% vs 18%, p = 0.026). No differences were found in other baseline or follow up characteristics. Our results support recent findings of dementia incidence in LOEU. Prospective studies on LOEU should evaluate phenotypic determinants of individuals with late life epilepsy and the rate of progression to dementia. |
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| Keywords: | Alzheimer Late onset epilepsy Epilepsy etiology Dementia risk |
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