Treatment outcome of posttraumatic stress disorder: A white matter tract analysis |
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| Affiliation: | 1. Department of Psychology, University of Cincinnati, USA;2. Anxiety Disorders Center, Hartford Hospital/Institute of Living, USA;3. University of Louisville, USA;4. VA VISN 20 Northwest Network Mental Illness Research, Education and Clinical Center (MIRECC), USA;5. Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, USA;6. Department of Psychological and Brain Sciences, University of Massachusetts Amherst, USA;7. School of Psychology, University of Southern Mississippi, USA;8. Department of Psychology, Florida State University, USA;1. Trauma Recovery Center, Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio USA;2. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio USA;1. Veterans Affairs Connecticut Health Care System, 950 Campbell Ave., West Haven, CT, 06516, United States;2. Department of Psychiatry, Yale School of Medicine, 300 George St., New Haven, CT, 06511, United States;3. National Center for PTSD, 163 Veterans Drive, White River Junction, VT, 05009, United States;4. U.S. Department of Veterans Affairs National Center on Homelessness among Veterans, 50 Irving ST. NW, Washington, DC, 20422, United States;5. School of Public Health, University of Texas Health Science Center at Houston, 1200 Pressler St., Houston, TX, 77030, United States;6. U.S. Department of Veterans Affairs National Center for PTSD, VA Connecticut Healthcare System, 950 Campbell Ave., West Haven, CT, 06516, United States;7. Department of Social and Behavioral Sciences, Yale School of Public Health, Laboratory of Epidemiology and Public Health, 60 College St., New Haven, CT, 06510, United States;1. Center for Imaging of Neurodegenerative Diseases, VAMC San Francisco, Clement Street 4150, San Francisco, CA 94121, USA;2. Department of Psychiatry, University of California, San Francisco, CA, USA;3. Department of Psychiatry, NYU School of Medicine, New York, NY, USA;4. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA;1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China;2. Shanghai Key Laboratory of Psychotic Disorders, PR China;3. Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China;4. Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, PR China;5. Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China;6. Shanghai Jiao Tong University School of Medicine, PR China |
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| Abstract: | Despite the development of empirically supported treatments for posttraumatic stress disorder (PTSD), many individuals remain symptomatic following therapy or dropout prematurely. Neuroimaging studies examining PTSD treatment outcome may offer valuable insights into possible mechanisms that may impact treatment efficacy. To date, few studies of PTSD have used neuroimaging to examine symptom change following completed treatment, and most have focused on gray matter. Studies of white matter are equally important, as changes in white matter integrity (WMI) are connected to a host of detrimental outcomes. The current study examined symptom change of 21 women with PTSD as a result of interpersonal violence who received baseline diffusion tensor imaging (DTI) scans and completed 12 weeks of Cognitive Processing Therapy (CPT). After controlling for baseline PTSD severity, fractional anisotropy (FA) in the left internal capsule, posterior limb of the internal capsule, left cingulate gyrus, superior longitudinal fasciculus, and splenium of the corpus callosum was predicted by PTSD symptom change. Results contribute to understanding neural changes within therapy and may assist in predicting individual treatment response. Namely, by identifying areas potentially impacted by PTSD treatment, future studies may be able to connect the function of these white matter areas to better predict patient PTSD treatment outcome. |
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| Keywords: | Posttraumatic stress disorder Treatment outcome Diffusion tensor imaging Interpersonal violence |
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