Severe periodontitis is associated with the serum levels of hypersensitive C reactive protein and lipoprotein-associated phospholipase A2 in the patients of acute ischemic stroke |
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| Institution: | 1. Cognitive Impairment Ward of Neurology Department, The Third Affiliated Hospital of Shenzhen University Medical College, Shenzhen City, Guangdong Province 518001, PR China;2. Department of Neurology, The Affiliated Yuebei People’s Hospital of Shantou University Medical College, Shaoguan, Guangdong Province 512025, PR China;3. Department of Psychiatry, The First Affiliated Hospital of Jinan University, Guangzhou City, Guangdong Province 510632, PR China;4. Department of Cardiology, The Third Affiliated Hospital of Shenzhen University Medical College, Shenzhen City, Guangdong Province 518001, PR China;5. Department of Neurology, People ’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 530021, PR China;6. Department of Neurology, Shunde Hospital of Southern Medical University, Shunde, Guangdong Province 528300, PR China;7. Department of Neurology, The Third People''s Hospital of Hangzhou, Hangzhou, Zhejiang Province 310009, PR China;1. Hospital Madre Teresa, Belo Horizonte, MG, Brazil;2. Hospital Municipal Miguel Couto, Rio de Janeiro, RJ, Brazil;3. University of Vanderbilt, School of Medicine, Nashville, TN, USA;4. Universidade Federal Fluminense, Rio de Janeiro, RJ, Brazil;1. Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan;2. Department of Orthopedics and Spine Surgery, Ichinomiyanishi Hospital, Ichinomiya, Japan;3. Department of Orthopedics and Spine Surgery, Meijo Hospital, Nagoya, Japan;1. Department of Neurosurgery, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia;2. Department of Neurosurgery, George Washington University School of Medicine and Health Sciences, Washington, DC, USA;1. Department of Orthopaedic Surgery, Walter Reed National Military Medical Center, Bethesda, MD, United States;2. Department of Surgery, The Uniformed Services University of the Health Sciences, Bethesda, MD, United States;3. Department of Orthopaedic Surgery, The Mayo Clinic, Rochester, MN, United States;4. Department of Neurosurgery, The Mayo Clinic, Rochester, MN, United States;1. Department of Surgery, University of Melbourne, Centre for Medical Research, 300 Grattan Street, Parkville, VIC 3050, Australia;2. Department of Neurosurgery, Royal Melbourne Hospital, 300 Grattan Street, Parkville, VIC 3050, Australia |
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| Abstract: | BackgroundPeriodontitis is associated with the pathogenesis of atherosclerotic plaque, and hypersensitive C reactive protein (hs-CRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) are the serum biomarkers of the stability of atherosclerotic plaque. Whether periodontitis is associated with the serum level of hs-CRP and Lp-PLA2 of acute ischemic stroke remains unclear.Material and MethodsWe recruited 103 cases with acute ischemic stroke within 7 days after stroke onset. Pocket depth and clinical attachment loss were assessed by oral examination to define the severe periodontitis. Demographic information including gender, age and body weight index, income level, education level, past medical history include smoking history, drinking history, ischemic stroke history, coronary heart disease, hypertension, diabetes and hyperlipidemia were collected, and serum biomarkers including white blood cell (WBC), fibrinogen, total cholesterol (TC), triglyceride (TG), lower density lipoprotein (LDL-C), high density lipoprotein (HDL-C), hs-CRP, HemoglobinA1c (HbAlc), Homocysteine (HCY) and Lp-PLA2 were tested.Results65 (63.1%) cases were diagnosed as severe periodontitis. Severe periodontitis group showed more male, age, drinking history, higher levels of hs-CRP and Lp-PLA2. Multivariate logistic regression showed that severe periodontitis was were significantly associated with hs-CRP (OR = 2.367, 95%CI: 1.182–4.738; P = .015) and Lp-PLA2 (OR = 2.577, 95% CI: 1.010–6.574; P = .048).ConclusionsSevere periodontitis is independently associated with the serum Level of hs-CRP and Lp-PLA2 in patients with acute ischemic stroke. Whether the improvement of periodontitis could decrease the occurrence and re-occurrence of ischemic stroke by stablizating atherosclerotic plaque need be further studied in future. |
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| Keywords: | Acute ischemic stroke Periodontitis Lipoprotein-associated phospholipase A2 |
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