High serum neurofilament levels among Chinese patients with aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders |
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Affiliation: | 1. Neurology Department, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China;2. Lui Che Woo Institute of Innovative Medicine, Division of Neurology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region;3. Perron Institute, University of Western Australia, Australia;4. Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, Xi’an, China;1. Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA;2. Department of Neurosurgery, Rhode Island Hospital, Providence, Rhode Island, USA;1. Department of Orthopaedic Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;2. Department of Orthopaedic Surgery, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;3. Department of Orthopaedic Surgery, Sanggye Paik Hospital, Inje University, Seoul, Republic of Korea;1. Dept. of Neurosurgery, SGPGIMS, Lucknow, India;2. Dept. of Pathology, SGPGIMS, Lucknow, India;3. Dept. of Neurosurgery, AIIMS, Jodhpur, India;1. School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA;2. Department of Radiology, Section of Neurointerventional Radiology, NYU Langone Health, New York, NY, USA;3. Department of Neurology, NYU Langone Health, New York, NY, USA;4. Department of Neurosurgery, NYU Langone Health, New York, NY, USA |
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Abstract: | BackgroundSerum neurofilament light chain (sNfL) is a promising biomarker for neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS), but there is limited validation data in specific ethnic and disease groups.ObjectiveTo investigate the levels of sNfL in a cohort of Chinese patients with NMOSD and compare sNfL levels in patients with different disease courses and treatments.MethodsWe analysed sNfL levels in 153 Chinese patients with NMOSD (n = 51) and MS (n = 102) using single-molecule array (Simoa) technology. The sNfL levels were compared with those of 71 healthy controls from two centres in southern China. For each disease, we assessed correlations between sNfL and disease phases and treatments.ResultsHigher levels of sNfL were found in the patients with NMOSD [17.97 (10.55–27.94) pg/mL] and MS [15.83 (8.92–25.67) pg/mL] compared to healthy controls [10.09 (7.19–13.29) pg/mL, p < 0.001]. No significant differences were found between the AQP4-IgG-positive NMOSD group and OCB-positive MS group.ConclusionssNfL measured by Simoa technology is a potential candidate blood biomarker for the diagnosis and disease monitoring of NMOSD in Chinese patients, warranting further prospective and multicentre studies. |
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Keywords: | Serum neurofilament light chain Neuromyelitis optica spectrum disorders Multiple sclerosis Chinese |
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