急性早幼粒细胞白血病免疫表型分析及临床意义

目的 分析急性早幼粒细胞白血病（APE）免疫表型特点及其临床意义。方法 采用流式细胞术检测31例APL患者的免疫表型。结果 31例患者中，CD33^＋30例（96.8％），CD13^＋27例（87．1％），CD33及CD13阳性共26例（83．9％）。CD34、CD2阳性分别为4例（12．9％）、5（16.1％）例。缓解组与未缓解组之间CD34、CD2表达差异有显著性意义（P〈0．01）。结论 APL免疫表型检测结合FAB分型可以提高诊断准确率，CD34、CD2是判断APL预后的重要免疫指标。

Clinical significance and analysis of immunophenotype in acute promyel-ocytic leukemia

Objective To investigate the immunophenoytpe of acute promyelocytic leukemia(APL) and its clinical significance.Methods Immunophenotype was examined by flow cytometry in 31 patients with APL.Results There were 30 cases who were positive for CD33(96.8%),27 positive for CD13(87.1%),26 positive both for CD33 and CD13(83.9%).CD34~-positive and CD2~-positive were in 4 and 5 cases respectively.There was statistic significance in complete remission group and no remission group(P<0.01). Conclusion The immunophenotype analysis of APL combined with FAB typing may improve the accurate rate of APL diagnosis.CD34 and CD2 are important indexes in judging the prognosis of APL.