Synthesis and antimicrobial evaluation of some novel 2-aminothiazole derivatives of 4-hydroxy-chromene-2-one |
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Authors: | Vukovic Nenad Sukdolak Slobodan Solujic Slavica Milosevic Tanja |
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Affiliation: | Faculty of Science, Department of Chemistry, Laboratory for Biochemistry, University of Kragujevac, Kragujevac, Serbia. nvukovic@kg.ac.yu |
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Abstract: | Syntheses of 2-aminothiazole derivatives of 4-hydroxy-chromene-2-one 2c-10c are reported in this paper. These compounds 2c-10c were prepared from 3-(2-bromoacetyl)-4-hydroxy-chromene-2-one 1 and corresponding thiourea derivatives 2b-10b using Hantzsch reaction. The structures of all compounds were confirmed by IR and( 1)H-NMR spectroscopy and elemental analyses. The molecules 2c-10c were evaluated for in vitro antimicrobial activity against ten bacteria and twelve fungi. All tested compounds exhibited antibacterial and antifungal activity. |
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Keywords: | Antibacterial activity Antifungal activity Coumarin Hantzsch reaction Thiazole derivatives |
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