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| 老年2型糖尿病患者血浆同型半胱氨酸与动脉粥样硬化的关系 | |
| 引用本文： | 郭远,苗懿德,宝辉,陈陵霞,杨素,郭琴.老年2型糖尿病患者血浆同型半胱氨酸与动脉粥样硬化的关系[J].中国医药导刊,2004,6(2):79-80. |
| 作者姓名： | 郭远 苗懿德 宝辉 陈陵霞 杨素 郭琴 |
| 作者单位： | 1. 北京大学人民医院老年医学科,北京,100044 2. 北京市门头沟区中医院,北京,102300 3. 北京军区卫生干部培训中心,北京,102300 |
| 摘 要： | 目的:探讨老年2型糖尿病患者血浆同型半胱氨酸(Homocysteine,HCY)与动脉粥样硬化的关系.方法:测定42例老年2型糖尿病患者和62例正常老年人的血浆HCY水平、颈动脉内中膜厚度(IMT)以及颈动脉(Carotid)、股动脉(Femoral)的斑块(Plaque)发生率.结果:糖尿病组血浆HCY水平明显高于对照组(P均＜0.01),颈动脉IMT及斑块发生率较对照组明显增加(P均＜0.05),其中合并早期糖尿病肾病者(IDN)与无并发症者(NIDN)相比,血浆HCY水平、颈动脉IMT及斑块发生率增加更明显(P均＜0.05).结论:血浆HCY升高可能是老年糖尿病动脉粥样硬化的独立危险因素之一,并与糖尿病微血管病变的发生有关. |
| 关 键 词： | 老年 2型糖尿病 血浆同型半胱氨酸 内中膜厚度 动脉斑块 |
Relationship between Homocysteine and Atherosclerosis in Type 2 Diabetes Mellitus Elderly |
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| Guo Yuan,Miao Yi - de,Bao Hui,et al..Relationship between Homocysteine and Atherosclerosis in Type 2 Diabetes Mellitus Elderly[J].Chinese Journal of Medicinal Guide,2004,6(2):79-80. | |
| Authors: | Guo Yuan Miao Yi - de Bao Hui |
| Abstract: | Objective: To investigate the relationship between the plasma HCY and atherosclerosis in type 2 diabetes mellitus (DM) elderly. Methods: We determined the plasma HCY level, carotid intimia - media thickness (IMT), carotid and femoral atherosclerotic plaques of 42 old DM patients and 62 normal elderly. Results: Compared with normal elderly subjects, DM patients generally have higher HCY level (P<0.01)and more severe atherosclerosis(P < 0.05). Furthermore, DM patients with incipient nephropathy (IDN) have higher HCY level (P < 0.05) and more atherosclerotic than that of patients without incipient nephropathy(NIDN) (P < 0.05). Conclusion: High HCY level is not only the independent risk factor of the large artery atherosclerosis in DM, but also closely related with pathogenesis of micnoangiopathy. |
| Keywords: | Elderly type 2 diabetes mellitus Homocysteine IMT Plaque |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |