热毒宁注射液治疗急性气管和支气管炎伴发热患儿的临床观察

目的探讨热毒宁注射液对急性气管／支气管炎伴发热患儿的疗效。方法2007年1月至2008年1月在我院儿科门诊及住院用热毒宁注射液治疗100例急性气管／支气管炎伴发热患儿，按随机数字表法分为治疗组和对照组各50例。2组患儿均采用儿科常规综合性治疗，在此基础上，治疗组应用热毒宁注射液，剂量按1～5岁0．5～0．8ml／（kg·d），5～10岁10ml／次，1次／d，加入5％葡萄糖溶液或生理盐水中静脉滴注。5—7d为1个疗程。观察治疗前后症状体征的变化以及外周血、肝功能、肾功能变化。结果治疗组治愈率为96％（48／50），对照组为60％（30／50），2组相比差异有统计学意义（P〈0．01），且治疗组无一例发生不良反应。结论热毒宁注射液对急性气管／支气管炎伴发热患儿的疗效较好，安全性较高。

Observation of Reduning Injection for children with acute tracheitis-bronchitis complicated with fever

Objective To observe the curative effect of Reduning on the children with the acute tracheitis-bronchitis complicated with fever. Methods One hundred acute tracheitis-bronchitis infants with fever during Janu-ary 2007 to January 2008 were divided into treatment group and control group by random number table with 50 cases in each group. All infants received routine treatment, and infants in treatment group got additional treatment of Re-duning Injection. Five to seven days were regarded as one course of treatment. The changes of clinical manifesta-tion, peripheral blood,hepatic function and renal function were observed. Results The cure rate was 96% and 70% in treatment group and control group respectively (P < 0.01 ). There was no adverse effect observed. Conclusion Reduning is effective and safe for children with the acute tracheitis-bronchitis complicated with fever.