溶血磷脂酸与CA125在复发性卵巢癌中的价值分析

目的 分析血浆溶血磷脂酸（lysophosphatidic acid,LPA）及CA125在卵巢癌复发患者中的表达情况和监测价值.方法 选择2013年1月-12月广州市第一人民医院收治的32例上皮性卵巢癌复发患者,测定血浆LPA和CA125表达情况,检测同期28例上皮性卵巢癌治疗后完全缓解患者、30例初诊上皮性卵巢癌患者及30例正常女性的血浆LPA和CA125作为对照,分析LPA和CA125在卵巢癌复发患者中的敏感度和特异度.结果 上皮性卵巢癌复发组血浆LPA（9.52±4.64 mol/L）明显高于完全缓解患者组（2.02±1.94 mol/L）（t=7.96,P＜0.05）及正常人群组（1.91±2.21 mol/L）（t=8.15,P＜0.05）,与初诊患者组（9.19±2.47 mol/L）差异无统计学意义（t=0.35,P＞0.05）,上皮性卵巢癌复发组血浆CA125（75.42±10.66 U/ml）明显高于完全缓解患者组（11.42±9.67 U/ml） （t=28.830,P＜0.05）及正常人群组（10.45±6.42 U/ml）（t=24.220,P＜0.05）,与初诊患者组（63.29±132.32 U/ml）差异无统计学意义（69.29±7.32 U/ml）（t=2.622,P＞0.05）.采用LPA和CA125诊断上皮性卵巢癌复发的诊断价值有差异（χ^2=37.834,P=0.022）,其中LPA敏感度（93.8％）高于CA125（65.6％）,特异度无明显差异（χ^2=24.501,P=0.99）.结论 LPA水平对判断上皮性卵巢癌的复发有重要价值,可能成为监测上皮性卵巢癌复发的新方法.

Significance of the Combined Lysophospholipids Acid and CA125 in Recurrence Ovarian Cancer

Objective To investigate and analyze the value and function of combined Lysophospholipids acid （LPA） and CA125 in monitoring the recurrence of epithelial ovarian cancer（EOC）.Methods 32 patients of recurrent EOC in 2013 were detected the level of LPA and CA125,and 28 patients with complete remission of EOC,30 first diagnosis of EOC patients,as well as 30 healthy women were chosen as control.Results LPA in patients of recurrent EOC （9.52±4.64 mol/L） were significantly higher than the complete remission patients （2.02 ± 1.94 mol/L,t=7.96,P〈0.05） and the 30 healthy women （1.91 ±2.21 mol/L,t=8.15,P〈0.05）,but no difference was found compared with first diagnosis patients （9.19 ± 2.47 mol/L,t=0.35,P〉0.05）.CA125 in patients of recurrent EOC （75.42 ± 10.66 U/ml） were significantly higher than the complete remission patients （11.42±9.67 U/ml,t=28.830,P〈0.05）and the 30 healthy women （10.45± 6.42 U/ml,t=24.220,P〈0.05）,but no difference was found compared with first diagnosis patients （69.29±7.32 U/ml,t=2.622,P〉 0.05）.The sensitivity of LPA （93.8%） in diagnosing recurrent EOC was better than CA125 （65.6%,χ^2 =37.834,P=0.022）,but no significant difference was found in specificity （χ^2 =24.501,P=0.99）.Conclusion The level of LPA play an important rule in the judgment of recurrent epithelial ovarian cancer,and combination of LPA and CA125 may become a new monitoring index for the recurrence of epithelial ovarian cancer.