肿瘤标志物检测对原发性肝癌早期诊断的分析

目的 探讨肿瘤标志物检测对原发性肝癌早期诊断的价值.方法 从门诊和住院患者当中选择原发性肝癌患者95例,检测AFP,CEA,CA199,CA125,CA724,FERR和NSE等肿瘤标志物.结果 原发性肝癌患者AFP,CEA,CA199,CA125,CA724,FERR和NSE的单项检出异常率分别为64.2％,19.6％,75.9％,78.0％,4.1％,43.7％和22.2％;AFP阳性和AFP阴性时,原发性肝癌患者FERR,CA199和CA125都有较高的阳性率;三种不同组合的肿瘤标志物对原发性肝癌患者检测的异常率分别为85.6％,89.4％和91.5％.结论 肿瘤标志物阴性时不能排除原发性肝癌,但组合检测可提高原发性肝癌的诊断率.

Study on the Tumor Markers for the Early Diagnostic Value of Primary Lepatic Carcinoma

Objective To investigate the detection of tumor markers for early diagnosis in primary hepatocellular carcinoma.Methods Selected 95 patients with primary hepatocarcinoma from the outpatients and inpatients and examined the AFP,CEA,CA199,CA125,CA724,FERR and NSE as tumor markers.Results The positive rates of tumor markers （AFP,CEA,CA199,CA125,CA724,FERR and NSE） in individual were 64.2 ％,19.6 ％,75.9 ％,78 ％,4.2 ％,43.8 ％ and 22.2 ％ respectively in patients with primary hepatocellular carcinoma.Whether the AFP was positive or negative,positive detection rates of the tumor markers （FERR,CA199,CA125） were high in patients with primary hepatocellular carcinoma.The different combination of three tumor markers positive rates were 85.6 ％,89.4 ％,91.5 ％ respectively in patients with primary liver cancer.Conclusion Although the detection of tumor markers were negative which did not exclude the hepatocellular carcinoma,but the accuracy of diagnosis could be improved according to combination of test results.