基于代谢组学的中医证候本质研究进展

中医证候的研究一直进展缓慢,其整体的功能状态难以用简单的临床化学指标或指标集成来表达,而新涌现的代谢组学无歧视代谢轮廓表达与中医整体观下的证候状态表述相互吻合,将代谢组学理念及技术用于中医证候的研究必将带来中医证候本质方面研究的新突破。本文综述了近年来中医证候的研究现状,并着重介绍了基于代谢组学的中医证候本质研究,主要包括动物造模的中医证候代谢组学和基于临床的证候代谢组学分析,以推进代谢组学在中医学领域的深入应用。

Study Achievements on the Nature of TCM Syndromes Based on Metabonomics

Development rate on research of TCM syndromes is slow. TCM syndromes are general functions and situations of the body. Simple clinical biomedical indicators or groups of indicators are unable to explain TCM syndromes properly. While the unbiased metabolite profiles, which is the new developed metabonomics, are in consistence with TCM syndromes based on holism concept. The import of ideas and technologies of metabonomics will bring a breakthrough on the research of the nature of TCM syndromes. This review highlights recent developments on the research of the nature of TCM syndromes. The utilization of metabonomics aims to facilitate the application of metabonomics in the field of TCM.