| 基于细胞的中药成分肾毒性研究 |
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| 引用本文： | 王 旗,刘 庆,沈晓帆,江 芳.基于细胞的中药成分肾毒性研究[J].世界科学技术-中医药现代化,2010,12(4):600-603. |
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| 作者姓名： | 王 旗 刘 庆 沈晓帆 江 芳 |
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| 作者单位： | 北京大学公共卫生学院毒理学系 北京 100191 |
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| 基金项目： | 北京市科委科技计划项目（Z0004105040311）：先导物和中药的ADMET性质快速集成评价实验平台，负责人：杨秀伟。 |
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| 摘 要： | 为探讨基于细胞的中药安全性评价新方法的有效性，本文对常用的肾小管上皮细胞的特点及其在中药成分体外肾毒性研究中的应用情况进行概述，并对基于细胞的中药肾毒性评价方法的应用前景进行展望。
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| 关 键 词： | 中药成分 肾毒性 细胞 安全性评价 |
| 收稿时间： | 2009/12/9 0:00:00 |
| 修稿时间： | 1/5/2010 12:00:00 AM |
Cell-based Approaches in Studying the Nephrotoxicity Induced by Components of Traditional Chinese Medicine |
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| Wang Qi,Liu Qing,Shen Xiaofan and Jiang Fang.Cell-based Approaches in Studying the Nephrotoxicity Induced by Components of Traditional Chinese Medicine[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2010,12(4):600-603. |
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| Authors: | Wang Qi Liu Qing Shen Xiaofan and Jiang Fang |
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| Institution: | Department of Toxicology, School of Public Health, Peking University, Beijing 100191, China |
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| Abstract: | The nephrotoxicity induced by traditional Chinese medicine(TCM), which is attracting more attention, hinders TCM development and clinical application. To gurantee the safe application of TCM, it is essential to, establish modern safety assessment approaches. During early toxicity screening, in vitro cytotoxicity assays were conducted to explore the cell-based approach for the safety assessment of TCM components. This paper briefly reviews the characteristics of renal tubular epithelial cells and the applications of cell-based approaches to in vitro study concerning the nephrotoxicity of TCM components. Perspectives are also presented regarding the use of renal tubular epithelial cells as an early safety assessment assay in TCM. |
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| Keywords: | TCM components Nephrotoxicity Cell-based Safety assessment |
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