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类风湿性关节炎寒热证候的生物学基础
引用本文:吕 诚,刘元艳,肖 诚,姜 淼,查青林,吕爱平. 类风湿性关节炎寒热证候的生物学基础[J]. 世界科学技术-中医药现代化, 2010, 12(5): 814-817
作者姓名:吕 诚  刘元艳  肖 诚  姜 淼  查青林  吕爱平
作者单位:中国中医科学院中医临床基础医学研究所 北京 100700;北京中医药大学 北京 100029;中日友好医院 北京 100029;中国中医科学院中医临床基础医学研究所 北京 100700;中国中医科学院中医临床基础医学研究所 北京 100700;中国中医科学院中医临床基础医学研究所 北京 100700
基金项目:科学技术部“十一五”国家科技支撑计划项目(2006BAI04A10):基于二次临床研究的中医药治疗类风湿性关节炎的临床评价,负责人:吕爱平;科学技术部国家“重大新药创制”科技重大专项项目(2009ZX09502原0190):基于辨证论治治疗RA 中药新药药效评价动物模型研制及其应用研究,负责人:吕爱平;国家科学技术部创新方法学专项项目(2008IM020900):中医药科学方法研究——中医药科学方法总论研究,负责人:吕爱平;国家自然科学基金杰出青年项目(30825047):中西医结合基础——疾病证候分类研究,负责人:吕爱平;国家自然科学基金项目(30902000):基于肾阳虚关节炎大鼠壮骨关节丸毒性反应评价研究,负责人:吕诚。
摘    要:疾病分类与证候分类结合的诊疗模式已经成为中医学和中西医结合医学临床实践的主要模式。本研究以类风湿性关节炎(RA)为例,比较RA 寒热证候与临床疗效的关联、寒热证候实验室常规指标及组学指标的差异,指出RA 寒热证候存在客观生物学基础,有助于RA 临床诊断和有效治疗。

关 键 词:疾病证候分类类 风湿性关节炎 寒证和热证 生物学基础
收稿时间:2010-10-13
修稿时间:2010-10-15

The Biological Basis of Cold and Heat Pattern of Rheumatoid Arthritis in Traditional Chinese Medicine
Lv Cheng,Liu Yuanyan,Xiao Cheng,Jiang Miao,Zha Qinglin and Lv Aiping. The Biological Basis of Cold and Heat Pattern of Rheumatoid Arthritis in Traditional Chinese Medicine[J]. World Science and Technology—Modernization of Traditional Chinese Medicine and Materia Medica, 2010, 12(5): 814-817
Authors:Lv Cheng  Liu Yuanyan  Xiao Cheng  Jiang Miao  Zha Qinglin  Lv Aiping
Affiliation:Institute of Basic Research In Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China;School of Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China;China-Japan Friendship Hospital, Beijing 100029, China
Abstract:An integrative mode of the disease classification in Western medicine and the syndrome differentiation in Chinese medicine is already the chief mode of sorting applied in clinical practice of Chinese medicine and integrative medicine. In this study, the cold and heat pattern of rheumatoid arthritis were comparatively analyzed. A range of facts, including the correlation of syndrome differentiations and therapeutic effects, the difference of laboratorialexamination and omics expression between cold and heat pattern of RA were reviewed to demonstrate the biological basis of RA syndrome differentiations. It indicates that the better knowledge of the biological basis involved in syndrome differentiations of Chinese medicine might help to choose the most appropriate treatment.
Keywords:Syndrome differentiation of disease   Rheumatoid arthritis   Cold pattern and heat pattern   Biological basis
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