基于凝胶网状结构的中药提取物与乳膏基质相容性研究——中药提取物对司盘60-吐温80 复配乳化剂乳膏的凝胶网络结构性能的影响

目的:探寻中药提取物对乳膏凝胶网状结构形成与稳定的影响。方法:以苦参碱、甘草次酸、小檗碱等6种中药提取物为模型药物,以司盘60-吐温80复配乳化剂制备乳膏,考察提取物在油相中的溶解性能、药物的油水界面活性,药物对乳膏宏观稳定性、凝胶网络结构和物化性质的影响。结果:苦参碱、甘草次酸和大黄素有促进乳膏凝胶网络结构形成与稳定的作用,黄芩苷和小檗碱降低乳膏凝胶网络结构形成与稳定的作用,丹皮酚对其影响不大。结论:中药提取物与乳膏基质相互作用所表现出的复杂理化性质,影响了凝胶网状结构形成、交联和溶胀。

Study on Compatibility between Herbal Extracts and Cream Matrix based on Gel Network-Influence of Herbal Extracts on Span 60-Tween 80 as Compound Emulsifier Cream Gel Network Structure

The study was aimed to investigate the influence of herbal extracts on the formation and stability of cream gel network. Matrine, glycyrrhetinic acid, emodin, paeonol, baicalin and berberinehydrochloride were taken as model drug. Span 60 and Tween 80 were used as compound emulsifier in the cream preparation. The herbal extracts were evaluated from aspects of drug solubility in oil, interaction with surfactants, interfacial activity between oil and water, visual stability of cream, gel network, physical and chemical properties. The results showed that matrine, glycyrrhetinic acid and emodin promote the formation and stability of gel network. Baicalin and berberinehydrochloride reduce the formation and stability of gel network. Paeonol has no significant impact on gel network. It is concluded that the complex physical and chemical properties of herbal extracts influence the effective formation, crosslinking and swelling of the gel network after the interaction with cream matrix.