丙氧锗二酸对顺铂毒性的保护作用及其对抗癌效果的影响

 本文研究了丙氧锗二酸（Ge－132）对顺铂毒性及抗癌效果的影响，并对其保护作用与金属硫蛋白（metallothionein，MT）的关系进行了探讨。结果表明Ge－132对顺铂引起的肾脏、血液和致死的毒性具有明显的保护作用。其效果优于次硝酸秘、亚硒醚钠以及氧化锗；Ge－132无诱导MT的作用，经体内抑瘤实验及体外细胞毒性实验表明，Ge－132对顺铂的抑瘤作用无统计学意义的影响。

Reduction of toxicity of cisplatin by Ge-132 without compromising itsantitumor activity in mice

The protective effects against the toxicity of cisplath(CDDP)as well as its anti-cancer efficiency were investigated in mice treated with Ge-132. The nephrotoxicity ,hemotoxicityand lethaI toxicity of CDDP were greatly reduced by administration of Ge-132 PO(P<0.01).The protective effects were better than GeO_2,Bi(BSN)and Se(Na_2SeO_3),which have been re-ported a lot previously, The determination of metallothionein(MT ) levels in the liver , kidney,heart andtumour of mice showed that Ge-132 did not induce the synthesis of MT。 So it couldn’tinduce the drug resistance made by MT. Otherwise the antitumor experiments showed that Ge-132 did not affect the efficiency of cell toxicitv of CDDP in vitro andits antitumor effect in vivo(P>0.05).These results suggested that Ge-132 might be a adjuvant of anticancer drugs to im-prove tbetherapeutic index of CDDP.