脂溢性角化病的研究进展

脂溢性角化病是老年人常见的表皮良性肿瘤,50岁后80%以上患病。近年的研究认为,日光和人类乳头瘤病毒感染与该病的发生密切相关,但确切机制不明。该病皮损绝大部分颜色较深,研究认为,是增生的角质形成细胞产生内皮素作用于黑素细胞所致。分子生物学方面的研究发现该病皮损中p53、Bcl-2、p73及p16等生物分子表达异常,引起细胞的分化、增殖、凋亡及细胞周期紊乱,从而参与疾病的发生。

Advances in Seborrheic Keratosis

Seborrheic keratosis (SK), usually seen in old people, is an epidermal benign tumor, and more than 80% people over 50 years old suffer from this disease. Recently, it has been shown that the exposure to sunlight and infection with human papilloma virus are closely related to the development of SK, but the exact mechanism is not clear. Most of the SK lesions are deep colored, and researches show that this is because the endothelin secreted by proliferative keratinocytes acts on melanocytes. Studies on molecular biology find that the expression of P53, Bcl-2, P73 and P16 in SK lesions is abnormal, which leads to the disorder of cell differentiation, proliferation, apoptosis and cell cycle, and eventually participate in the occurrence of this disease.