Proportion of Multidrug-Resistant Tuberculosis in Human Immunodeficiency Virus/Mycobacterium tuberculosis Co-Infected Patients in Korea |
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| Authors: | Joon Sung Joh H. Christian Hong In A Jeong Bum Sik Chin Hye Jin Yang Hongjo Choi Ji Hwan Bang |
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| Affiliation: | 1Department of Internal Medicine, National Medical Center, Seoul, Korea.;2Center for Respiratory Diseases, National Medical Center, Seoul, Korea.;3Center for Infectious Diseases, National Medical Center, Seoul, Korea.;4International Tuberculosis Research Center, Changwon, Korea.;5Division of Infectious Diseases, Seoul National University-Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea. |
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| Abstract: | Much controversy surrounds the issue of whether HIV infection is a risk factor for developing multidrug-resistant tuberculosis (MDR-TB). In this study, we evaluated the prevalence of and risk factors for MDR-TB in HIV-infected patients at the National Medical Center of Korea. We reviewed the medical records of HIV/TB co-infected patients from January 2005 to May 2011; the drug susceptibility profiles were available for 55 patients. Of these, 32.7% had MDR-TB, which was approximately 3.6 times higher than the prevalence among the general population. Additionally, there were more additional AIDS-defining clinical illnesses in the MDR-TB group than in the non-MDR-TB group (27.8% vs 5.4%, P = 0.032). These results suggest that HIV infection and HIV-related immunosuppresion may contribute to the development of MDR-TB. |
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| Keywords: | Tuberculosis Multidrug-Resistant Tuberculosis HIV |
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