短暂性脑缺血患者血清C反应蛋白水平与脑血栓形成的关系

目的：观察短暂性脑缺血发作（TIA）患者血清C反应蛋白 (CRP) 的水平，探讨CRP与其他危险因素的关系。方法：102例TIA患者根据病程分为两组，即在2周内进展为脑梗塞者为进展组(n= 40)，未继续进展者为未进展组(n=62)。所有患者在入院24 h内首次测定血清CRP水平，同时测血压（BP）、血糖（BS），纤维蛋白原（FIB）、血脂参数如总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL-L）、低密度脂蛋白（LDL-L）。67例健康体检者作为对照组。CRP分别与上述8个指标进行相关性分析。结果：①TIA组的CRP血清水平高于正常对照组（P<0.05），且进展组高于未进展组（P<0.05）。②相关性分析显示，CRP与BP、BS、TG、FIB均呈显著性正相关关系(P<0.01，γ值分别是0.517、0.439、0.533、0.406)。结论：CRP是评价TIA患者短期内是否进展为完全性卒中的一个非特异性的、新的血清学指标；CRP血清水平越高，TIA发展为脑梗塞的可能性越大。

Relationship between levels of serum CRP and cerebral thrombosis in patients with transient ischemia attack

Objective To observe the serum level of C-reactive protein(CRP) in transient ischemic attack(TIA) patients,and to assess the correlation between CRP and other dangerous factors of cerebral infarction.Methods 102 TIA patients were divided into two groups: TIA deteriorated into cerebral infarction in two weeks(group A,n=40) and TIA could be relieved in two weeks(group B,n=62).Many factors were measured within 24 h,such as CRP,BP,BS,FIB,TC,TG,HDL-L,and LDL-L.67 healthy subjects were usded as control group.Relative analysis was performed between CRP and 8 parameters mentioned above.Results ①The serum CRP level of TIA patients was higher than that of healthy controls(P<0.05).It was also higher in group A than that in group B(P<0.05).②The correlative analysis demonstrated that the serum CRP level had obviously positive relationships with BP,BS,FIB and TG(P<0.01),the γ values were 0.517,0.439,0.533,and 0.406,respectively.Conclusion CRP is a non-differential,but very important new serum symbol to evaluate whether TIA evolves to cerebral infarction in a short period of time.The higher serum CRP level is,the more probably TIA evolves to complete stroke.