| Association of the Platelet Glycoprotein Ⅰa C807T Gene Polymorphism With Risk of Myocardial Infarction in Chinese |
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| 作者单位： | Zhao Qingbin（Department of Cardiology, The First Affiliated Hospital, Xi'an Jiao Tong University, Xi'an 710061, China） ;
Ma Aiqun（Department of Cardiology, The First Affiliated Hospital, Xi'an Jiao Tong University, Xi'an 710061, China） ;
Sun Chaofeng（Department of Cardiology, The First Affiliated Hospital, Xi'an Jiao Tong University, Xi'an 710061, China） ; |
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| 摘 要： | Objectives To investigate the relationship of the GPIa C807T dimorphism to the risk of myocardial infarction (MI) in Chinese. Methods We did a case-control study including 100 patients and 110 controls with same race. An allele-specific polymerase chain reaction (PCR) was used for genotyping of C807T polymorphism. Results An apparent association was found between the T807 allele and MI among individuals younger than the mean age of 60 years (odds ratio,2.49; 95% confidence interval, 1.08 ～ 6.22 ). The T807 allele remained an independent risk factor for MI when age, sex, smoking, hypertension, diabetes, bodymass index, LDL-cholesterol and HDL-cholesterol were adjusted by logistic regression. Conclusions GPⅠa T807 appears to be an independent risk factor for MI.
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