肾小球滤过功能检测在糖尿病肾病中的诊断价值

目的探讨血清胱抑素C（Cys-C）、血清肌酐（Scr）、尿素（Urea）和肌酐清除率（Ccr）在糖尿病肾病患者中的早期诊断价值。方法将128例2型糖尿病患者按24h尿微量白蛋白水平分为3组,A组为正常蛋白尿患者49例（UMA〈30mg/24h）,B组为微量蛋白尿患者45例（UMA30～300mg/24h）,C组为大量蛋白尿患者34例（UMA〉300mg/24h或常规蛋白阳性）,测定血清胱抑素C（Cys-C）、血清肌酐（Scr）、尿素氮（Urea）,并计算肌酐清除率（Ccr）。结果血清胱抑素C（Cys-C）在各组间差异有统计学意义（P〈0.01）;而Scr、Urea、Ccr在A组和B组间差异无统计学意义（P〉0.05）;C组的Scr、Urea、Ccr高于A组和B组,差异有统计学意义（P〈0.01）。结论血清胱抑素C是糖尿病肾病早期诊断的敏感指标。

Diagnostic value of glomerular filtration function detection for diabetic nephropathy

Objective To explore the value of serum cystatin-C, serum creatinine(Scr), urea and creatinine clearance rate (Ccr) in the early diagnosis of diabetic nephropathy. Methods According to urine microalbum of 24 hours, 128 patients with type 2 diabetes were divided into 3 groups. A group had 48 patients with normal albumiuria, B group had 45 patients with microalbumiuria, C group had 34 patients with macroalbumiuria. Serum cystatin-C, serum creatinine and urea were measured, and creatinine clearance rate were calculated. Results Serum cystatin-C was different among the three groups(P < 0.01), but serum creatinine, Urea, and creatinine clearance rate were not different between A group and B group, serum creatinine, urea and creatinine clearance rate of C group were higher than A group and B group. Conclusion Serum cystatin-C is a sensitive parameter in diagnosing early diabetic nephropathy.