A minor subset of HLA-DR3 haplotypes is preferentially increased in Type 1 (insulin-dependent) diabetes |
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| Authors: | M. J. Sheehy J. R. Rowe T. C. Fuller E. J. Yunis K. H. Gabbay |
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| Affiliation: | (1) Section of Endocrinology, Department of Medicine, University of Wisconsin, Madison, Wisconsin;(2) American Red Cross Blood Services, Madison, Wisconsin;(3) Diabetes Unit, Children's Hospital Medical Center, Boston, Massachusetts, USA;(4) Division of Immunogenetics, Dana/Farber Cancer Institute, Boston, Massachusetts, USA;(5) Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA;(6) Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA;(7) Present address: Department of Pediatrics, Baylor College of Medicine, 77030 Houston, Texas, USA |
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| Abstract: | Summary We have been using human T-lymphocyte clones specifically sensitized to detect leucocyte antigens of Type 1 (insulin-dependent) diabetic patients in the hope of detecting novel HLA antigens associated with Type 1 diabetes. We previously described two such clones which define a new class II HLA antigen, Boston-1 (BO1). BO1 is found mainly on cells of persons with particular HLA-DR antigens and, of potential significance for diabetes, BO1 identifies a distinctive subset of DR3 haplotypes. We report here that BO1+ DR3 haplotypes are overrepresented in Type 1 diabetes. That is, significantly more of the DR3-positive subjects are BO1-positive in the patient group (31%) than in the control group (8%), suggesting that a diabetes-susceptibility gene may be more common on the BO1+ than on the BO1– DR3 haplotypes. Alternative interpretations are also discussed. |
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| Keywords: | Type 1 (insulin-dependent) diabetes genetics HLA antigens T-lymphocyte clones |
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