布洛芬微晶体在口腔崩解片中的应用

目的：改善口腔崩解片干粉压片工艺中药物的可压性、流动性、黏冲性，提高崩解片的崩解速度。方法：以布洛芬为模型药物，利用溶剂-非溶剂法改变其结晶形态，获得5种不同的微晶体，并用扫描电镜（SEM）和X衍射仪（XRD）表征。通过各晶体的压片工艺性能测试及压片后的崩解实验，优选出性能良好的晶体，并对其压制的崩解片进行了体外洛出性能的测定。结果：优选出的微晶体具有良好的可压性、流动性和抗黏冲性能，压片后崩解时限大大缩短，溶出度也有一定的提高。结论：优选出的布洛芬微晶体改善了口腔崩解片的整体性能。

Disintegration behavior of ibuprofen microcrystal from orally disintegrating tablets

Objective:To improve the tablet disintegration by selecting appropriate mierocrystal of drug powders to prepare orally disintegrating tablets.Methods:Five types of ibuprofen microcrystal were made by solvent-nonsolvent crystallization technique.The microcrystal was characterized by scanned electronic microscopy(SEM)and X-ray detector(XRD),respectively.The optimal crystals were ob- tained by the feature tests of compressibility and flowability and the dissolution test of the orally disinte- grating tables.Results:The optimal microcrystal had better compressibility,flowability and resistance to sticking to a die well.The orally integrating tablets made of the optimal microcrystal showed improved dissolution and solubility.Conclusion:The optimal mierocrystal improved the integrated behavior of ibu- profen orally disintegrating tablet.