| 酶法测定盐酸氟桂利嗪胶囊溶出度的考察 |
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| 引用本文： | 彭彩萍,邓茂芝,龙玉琼.酶法测定盐酸氟桂利嗪胶囊溶出度的考察[J].中国药业,2007,16(4):41-42. |
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| 作者姓名： | 彭彩萍 邓茂芝 龙玉琼 |
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| 作者单位： | 江西省宜春市药品检验所,江西,宜春,336000 |
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| 摘 要： | 目的建立有效的体外溶出度测定方法。方法采用在溶出介质中加酶与不加酶两种方法分别测定不同厂家的盐酸氟桂利嗪胶囊的溶出度，并将两法测定结果进行比较。结果与结论对用药典法测定的溶出度不合格的盐酸氟桂利嗪胶囊，两法的测定结果有显著性差异。
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| 关 键 词： | 盐酸氟桂利嗪 胶囊溶出度 胃蛋白酶 |
| 文章编号： | 1006-4931（2007）04-0041-02 |
| 收稿时间： | 2006-01-13 |
| 修稿时间： | 2006-04-10 |
Study on Dissolubility of Flunarizine Hydrochloride Capsule by Enzymologic Method |
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| Peng Caiping,Deng Maozhi,Long Yuqiong.Study on Dissolubility of Flunarizine Hydrochloride Capsule by Enzymologic Method[J].China Pharmaceuticals,2007,16(4):41-42. |
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| Authors: | Peng Caiping Deng Maozhi Long Yuqiong |
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| Affiliation: | Peng Caiping, Deng Maozhi, Long Yuqiong, (Yichun Institute for Drug Control of Jiangxi Province, Yichun, Jiangxi, China 336000) |
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| Abstract: | Objective To establish a valid method of in vitro dissolubility determination. Methods The two methods with or without pepsin in the menstruum were used to determine the dissolubility of flunarizine hydrochloride capsule produced by the different factories. The results of the two methods were compared and analyzed with the mathematical statistics. Results and Conclusion The results of the two methods have significant difference in the flunarizine hydrochloride capsules with unqualified dissolubility determined with the method according to the Chinese Pharmacopoeia. |
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| Keywords: | flunarizine hydrochloride capsule dissolubility pepsin |
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