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| 胃癌组织中B7-H4的表达及其临床意义 | |
| 引用本文： | 郭莉婷,陈颖,程月新,邵伟伟,顾晓怡,姜藻.胃癌组织中B7-H4的表达及其临床意义[J].东南大学学报(医学版),2010,29(3):306-311. |
| 作者姓名： | 郭莉婷 陈颖 程月新 邵伟伟 顾晓怡 姜藻 |
| 作者单位： | 1. 东南大学附属中大医院,肿瘤科,江苏,南京,210009 2. 苏州市立医院本部,江苏,苏州,215000 3. 盐城市第一人民医院,江苏,盐城,224001 |
| 摘 要： | 目的:探讨B7-H4在胃癌组织中的表达及其与临床病理及预后的关系。方法:应用逆转录聚合酶链反应(RT-PCR)技术及免疫组织化学染色检测胃癌患者手术切除组织标本中B7-H4的表达水平。结果:B7-H4 mRNA在20例胃癌组织和癌旁正常组织中均有表达,胃癌组织中表达明显高于癌旁正常组织;在80例胃癌组织中有60例B7-H4蛋白呈阳性表达(75%);B7-H4蛋白的表达与患者性别、年龄、组织类型、肿瘤大小、淋巴结转移、病理分期、浸润深度无关(均P>0.05);生存期>5年的胃癌患者B7-H4蛋白表达阳性率低于生存期≤5年的胃癌患者(P |
| 关 键 词： | B7-H4 免疫组织化学 逆转录聚合酶链反应 胃癌 预后 |
Expression and clinical significance of B7-H4 in gastric carcinoma tissues |
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| GUO Li-ting,CHEN Ying,CHENG Yue-xin,SHAO Wei-wei,GU Xiao-yi,JIANG Zao.Expression and clinical significance of B7-H4 in gastric carcinoma tissues[J].Journal of Southeast Univ: Medical Sci Ed,2010,29(3):306-311. | |
| Authors: | GUO Li-ting CHEN Ying CHENG Yue-xin SHAO Wei-wei GU Xiao-yi JIANG Zao |
| Institution: | GUO Li-ting1,CHEN Ying2,CHENG Yue-xin3,SHAO Wei-wei3,GU Xiao-yi1 JIANG Zao1 |
| Abstract: | Objective: To study the expression of B7-H4 in the gastric carcinoma tissues,to investigate the relationship between the expression of B7-H4 and the clinicopathological features.Methods: The expression of B7-H4 mRNA and B7-H4 protein in the gastric carcinoma tissues and nearby normal tissues were detected by RT-PCR and immunohistochemistry assay respectively.Result: The expression of B7-H4 mRNA was in both gastric carcinoma tissues and nearby normal tissues,the expression of BT-H4 in gastyic carcinoma tissu... |
| Keywords: | B7-H4 immunohistochemistry RT-PCR gastric carcinoma prognosis |
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