| 六味地黄丸对2型糖尿病大鼠胰岛形态的影响 |
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| 引用本文： | 袁琳,陆雄,张永煜,陆灏,毛泉明,叶进,韩志芬,林敏,白永生.六味地黄丸对2型糖尿病大鼠胰岛形态的影响[J].辽宁中医药大学学报,2009(3). |
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| 作者姓名： | 袁琳 陆雄 张永煜 陆灏 毛泉明 叶进 韩志芬 林敏 白永生 |
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| 作者单位： | 上海中医药大学; |
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| 基金项目： | 上海市科委局管项目(05JG05052);;上海市重点学科建设项目资助(TO301) |
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| 摘 要： | 目的:研究六味地黄丸对高糖高脂饲料喂养联合低剂量链脲佐菌素(streptozotocin,STZ)注射的2型糖尿病大鼠胰岛形态的影响。方法:高糖高脂饲料喂养5周后腹腔注射低剂量的STZ(40mg/kg)制备大鼠2型糖尿病模型。予六味地黄丸水煎剂治疗3周,动态观察治疗后的饮食量、体重、空腹血糖(FBG)变化,3周末检测血清游离脂肪酸(FFA)、甘油三酯(TG)、血清胰岛素(INS)水平,计算胰岛素敏感性指数(ISI),并在光镜和透射电子显微镜下观察胰腺形态学变化。结果:与模型组比较,六味地黄丸组在用药2周末饮水量明显减少,3周末进食量减少,FBG出现降低的趋势,FFA降低,ISI显著升高,形态学显示胰岛β细胞数量增多,细胞内分泌颗粒丰富,胰岛周边部导管上皮样细胞增多,并向胰岛中央移行。结论:六味地黄丸对高糖高脂饲料喂养联合低剂量STZ注射的2型糖尿病大鼠胰岛结构具有保护作用。
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| 关 键 词： | 六味地黄丸 2型糖尿病 动物实验 |
Therapeutic Effects of Liuwei Dihuang Wan on Type 2 Diabetes Rats Model |
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| YUAN Lin,LU Xiong,ZHANG Yong-yu,LU Hao,MAO Quan-ming,YE Jin,HAN Zhi-fen,LIN min,BAI Yong-sheng.Therapeutic Effects of Liuwei Dihuang Wan on Type 2 Diabetes Rats Model[J].Journal of Liaoning University of Traditional Chinese Medicine,2009(3). |
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| Authors: | YUAN Lin LU Xiong ZHANG Yong-yu LU Hao MAO Quan-ming YE Jin HAN Zhi-fen LIN min BAI Yong-sheng |
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| Institution: | Shanghai University of TCM;Shanghai 201203;China |
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| Abstract: | Objective:To investgate the effects of Liuwei Dihuang Wan on morphological change of pancreas islets in type 2 diabetes rats imodel. Methods:SD male rats were used to establish Type 2 diabetes rat model by injecting with streptozotocin(STZ) 40mg/kg after feeding with high-fat, high-sucrose diet for 5 weeks. Then the model rats were randomly divided to treat with Liuwei Dihuang Wan or vehicle orally for 3 weeks. FBG, body weight, food and water intake were monitored weekly. Free fatty acid (FFA), triglycerid... |
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| Keywords: | Liuwei Dihuang Wan type 2 diabetes animal experiment |
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