| 显微手术切除联合瘤腔植入缓释氟尿嘧啶和125Ⅰ治疗胶质瘤的临床观察 |
| |
| 引用本文： | 袁绍纪,吕学明,李际文,张荣伟,刘子生,孙希炎,卢培刚,朱伟杰,吕福林.显微手术切除联合瘤腔植入缓释氟尿嘧啶和125Ⅰ治疗胶质瘤的临床观察[J].中华肿瘤防治杂志,2010,17(1). |
| |
| 作者姓名： | 袁绍纪 吕学明 李际文 张荣伟 刘子生 孙希炎 卢培刚 朱伟杰 吕福林 |
| |
| 作者单位： | 1. 济南军区总医院神经外科全军神经外科专科中心,山东,济南,250031
2. 章丘市人民医院神经外科,山东,章丘,250200 |
| |
| 摘 要： | 目的:探讨外科显微手术切除联合瘤床内植入5-氟尿嘧啶(5-FU)多聚缓释体局部化疗和125Ⅰ局部放疗治疗胶质瘤的疗效.方法:65例胶质瘤行开颅显微手术切除,术中瘤床周围植入5-FU多聚缓释体和125Ⅰ粒子,术后每3个月立体定向引导再次植入1～2次.观察疗效和瘤周水肿情况及不良反应.结果:术后1周内头痛明显,脑脊液白细胞不同程度的升高,瘤周水肿较单纯手术明显,经治疗所有患者都顺利出院.随访6个月～5年,39例患者获完全随访;患者生存36例.结论:手术切除肿瘤联合瘤床内植入缓释5-FU多聚缓释体局部化疗和125Ⅰ局部放疗,是治疗胶质瘤的一种有效地方法.
|
| 关 键 词： | 神经胶质瘤/外科学 神经胶质瘤/药物疗法 药物植入物 碘放射性同位素 |
Treatment of malignant intracranial neoplasms by surgical excision conbined with the chemotherapy of intraccerebral implantation of 5-FU biodegradable polymer and radiochemotherapy with interstitial implantation of 125I |
| |
| YUANShao-ji,L%ee%%eXue-ming,LIJi-wen,ZHANGRong-wei,LIUZi-sheng,SHUNXi-yan,LUPei-gang,ZHUWei-jie,L%ee%%eFu-lin.Treatment of malignant intracranial neoplasms by surgical excision conbined with the chemotherapy of intraccerebral implantation of 5-FU biodegradable polymer and radiochemotherapy with interstitial implantation of 125I[J].Chinese Journal of Cancer Prevention and Treatment,2010,17(1). |
| |
| Authors: | YUANShao-ji L%ee%%eXue-ming LIJi-wen ZHANGRong-wei LIUZi-sheng SHUNXi-yan LUPei-gang ZHUWei-jie L%ee%%eFu-lin |
| |
| Institution: | YUAN+Shao-ji1,L%ee%90%9e+Xue-ming1,LI+Ji-wen2,ZHANG+Rong-wei1,LIU+Zi-sheng1,SHUN+Xi-yan1,LU+Pei-gang1,ZHU+Wei-jie1,L%ee%90%9e+Fu-lin11.Department+of+Neurosurgery,Jinan+General+Hospital+of+PLA,Neurosurgery+Center+of+PLA,Jinan+250031,P.R.China2.Department+of+Neurosurgery,People%5c's+Hospital+of+Zhangqiu,Zhangqiu+250200,P.R.China |
| |
| Abstract: | OBJECTIVE:To investigate the effectiveness of treatment of malignant intracranial neoplasms by surgical excision conbined with the chemotherapy of intraccerebral implantation of 5-FU biodegradable polymers and radiochemotherapy with interstitial implantation of 125I. METHODS:In 15 patients with malignant intracranial neoplasms,the tumor was surgically removed and 5-FU biodegradable polymers and 125I seeds were implanted during operation in the tumor bed and postoperation. The patients were implanted for 1-2... |
| |
| Keywords: | glioma/surgery glioma/drug therapy drug implants iodine radioisotopes |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
