THE EFFECTS OF SOME COMPOUNDS ON THE ENDOGENOUS RESPIRATION OF SKIN |
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| Authors: | V. J. W. LONG H. J. YARDLEY |
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| Affiliation: | M.R.C. Unit on the Experimental Pathology of Skin, The Medical School, The University, Birmingham 15 |
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| Abstract: | SUMMARY.— The effects of 2-bromostearic acid, 2: 4-dinitrophenol and menadione on the respiration of skin slices in the presence or absence of added glucose was measured. All 3 compounds depress endogeneous respiration, whereas in the presence of added substrate, 2-bromostearic acid has no effect and 2: 4-dinitrophenol and menadione stimulate respiration. Since cells in the upper part of the epidermis are in a giucose-free environment, it is suggested that in vitro tests of potentially toxic substances should be performed both in the presence and in the absence of glucose. |
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