| Dynamic Analysis of the Expression of HSP70 during Experimental Tooth Movement in Rats |
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| 作者姓名： | 毛靖 齐娟 李平 谢晖 |
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| 作者单位： | Center of Stomatology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology，Center of Stomatology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology，Center of Stomatology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology，Center of Stomatology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology，Wuhan 430030 China，Wuhan 430030 China，Wuhan 430030 China，Wuhan 430030 China |
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| 摘 要： | HSPs are highly conservative and omnipresent incells. The functions of HSPs are to protect cells and fa-cilitate recovery from various kinds of stimuli, thusmaintaining cells’ existence1]. Recently, HSPs are a hotspot in the study on reducing damage and promotingrecovery. Under the orthodontic force, damage and re-covery of the periodontium takes place following thetooth movement. HSP70 is the most important group inthe HSP family, but there is no report about its expres-sion pattern a…
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| 关 键 词： | 动力分析 基因表达 牙齿 HSP70 |
| 收稿时间： | 2006-10-31 |
| 修稿时间： | 2006-10-31 |
Dynamic analysis of the expression of HSP70 during experimental tooth movement in rats |
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| Jing Mao,Juan Qi,Ping Li,Hui Xie.Dynamic Analysis of the Expression of HSP70 during Experimental Tooth Movement in Rats[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2006,26(6):706-708. |
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| Authors: | Jing Mao Juan Qi Ping Li Hui Xie |
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| Institution: | Center of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030,China |
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| Abstract: | In this study, the expression of HSP70 during experimental tooth movement was dy-namically observed and the relationship between HSP70 and orthodontic periodontal tissue remodel-ing were observed. The orthodontic appliance was placed between the right maxillary first molar and maxillary central incisors of adult SD rats to establish a rat molar movement model. Immunohisto-chemistry was performed 1, 3, 5, 7 and 14 day(s) after orthodontic force application to observe the expression and localization of inducible HSP70. The expression of HSP70 was strongly positive in the early stage of the tooth movement, became gradually less positive, and was weakly positive in the restoration stage. There was difference in staining pattern between different parts of PDL during the same period. These results suggest that the expression of HSP70 and difference in staining pattern among different parts of PDL during orthodontic tooth movement in rats may be implicated in stress response and remodeling of periodontal tissue. |
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| Keywords: | orthodontic tooth movement immunohistochemistry heat shock protein 70 |
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