脆性组氨酸三联体基因转录外显子丢失与肝细胞癌易感性的Meta分析

目的 探讨脆性组氨酸三联体（Fhit）基因外显子丢失与肝细胞癌（HCC）发病风险的关系。方法 检索PubMed、CNKI、万方等数据库，收集有关Fhit基因转录外显子丢失与HCC易感性的病例对照研究，并从纳入文献中提取数据进行Meta分析。结果 最终纳入7个研究，涉及肝炎病毒相关HCC162例，对照组170例包括癌旁肝硬化组织136例，正常肝组织34例。HCC组与对照组Fhit外显子丢失比较的OR=5.02（95%CI: 2.99~8.43，P<0.00001）；亚组分析显示，HCC组与癌旁肝硬化组织组比较的OR=3.55（95%CI: 2.06~6.13，P<0.00001）；癌旁肝硬化组织组与正常肝组织组比较的OR=8.23（95%CI: 1.47~45.94，P=0.02）。结论 Fhit基因转录过程中外显子丢失可能是HCC发生的危险因素；肝炎病毒可能作用于肝细胞Fhit基因脆性位点造成其转录过程中外显子丢失，引起肝细胞恶变。

Relationship Between Fragile Histidine Trial Gene Exon Loss and Susceptibility of Hepatocellular Carcinoma: A Meta-analysis

Objective To investigate the relationship between Fhit gene exon loss and risk of hepatocellular carcinoma(HCC). Methods By searching PubMed, CNKI, Wanfang Database, et al, the case-control studies about the relationship between Fhit gene exon loss and the risk of HCC were chosen. Then the Meta-analysis was conducted using odd rate(OR) and 95% confidential interval(CI) to assess the strength of association. Results Seven studies were finally chosen, including 162 hepatitis virus-related HCC cases and 170 controls(136 tumor-adjacent cirrhosis and 34 normal liver tissues). The risk of Fhit gene exon loss was higher in the HCC group than that in the control group(OR=5.02, 95%CI: 2.99-8.43, P<0.00001). Subgroup analysis showed the risk of Fhit gene exon loss was higher in HCC tissues than that in tumor-adjacent cirrhosis tissues(OR=3.55, 95%CI: 2.06-6.13, P<0.00001); and it was also higher in tumor-adjacent cirrhosis tissues than that in normal liver tissues(OR=8.23, 95%CI: 1.47-45.94, P=0.02). Conclusion Fhit gene exon loss may be notably correlated with hepatocellular carcinoma, and HBV or HCV may play a role in the development of HCC through leading the Fhit gene exon loss.