| H3K27甲基化与EZH2在B细胞非霍奇金淋巴瘤中表观遗传调控的研究进展 |
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| 引用本文： | 邓玉洁,朱伟峰,陈刚,陈君敏. H3K27甲基化与EZH2在B细胞非霍奇金淋巴瘤中表观遗传调控的研究进展[J]. 肿瘤防治研究, 2015, 42(12): 1262-1266. DOI: 10.3971/j.issn.1000-8578.2015.12.020 |
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| 作者姓名： | 邓玉洁 朱伟峰 陈刚 陈君敏 |
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| 作者单位： | 1. 350005 福州，福建医科大学附属第一医院化疗科；2. 350014 福州，福建医科大学教学医院 福建省肿瘤医院病理科；3.350005 福州，福建医科大学附属第一医院血液风湿科 |
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| 摘 要： | 异常的组蛋白修饰与DNA甲基化是表观遗传学研究的重要领域，两者相互作用可导致特定基因的转录激活或抑制。H3K27的甲基化水平及其甲基转移酶EZH2可能与B细胞非霍奇金淋巴瘤（B-cell NHL）的特殊分型及不良预后密切相关。本文着重介绍H3K27me3与EZH2在B细胞非霍奇金淋巴瘤中的发生和发展过程的作用及相应机制。
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| 关 键 词： | B细胞非霍奇金淋巴瘤 H3K27me3 EZH2 DNA甲基化 |
| 收稿时间： | 2015-02-27 |
Progress of Epigenetic Regulation of H3K27me3 and EZH2 in B-cell Non-Hodgkin's Lymphoma |
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| DENG Yujie,ZHU Weifeng,CHEN Gang,CHEN Junmin. Progress of Epigenetic Regulation of H3K27me3 and EZH2 in B-cell Non-Hodgkin's Lymphoma[J]. Cancer Research on Prevention and Treatment, 2015, 42(12): 1262-1266. DOI: 10.3971/j.issn.1000-8578.2015.12.020 |
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| Authors: | DENG Yujie ZHU Weifeng CHEN Gang CHEN Junmin |
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| Affiliation: | 1. Department of Chemotherapy, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China; 2. Department of Pathology, Fujian Provincial Cancer Hospital, Teaching Hospital of Fujian Medical University, Fuzhou 350014, China; 3. Department of Hematology and Rheumatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China |
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| Abstract: | Aberrant modification of histone and DNA methylation are important fields in epigenetic research. Interaction between them often results in the activation or inhibition of specific genes. Methylation level of histone H3 lysine 27 and its methyltransferase EZH2 are closely correlated with specific classification of B-cell non-Hodgkin's lymphoma (B-cell NHL) and its prognosis. This paper emphatically introduces the roles that H3K27me3 and EZH2 might play in the onset and development of B-cell NHL, and the possible mechanism as well. |
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| Keywords: | B-cell non-Hodgkin’s lymphoma H3K27me3 EZH2 DNA methylation |
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